Recognition and stabilization of peptide α-helices using templatable nanoparticle receptors
Recognition and stabilization of peptide α-helices using templatable nanoparticle receptors
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DOI：
10.1021/ja047719h
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发表时间：
2004-09-08
影响因子：
15
通讯作者：
Rotello, VM
中科院分区：
文献类型：
--
作者：
Verma, A;Nakade, H;Rotello, VM
α-螺旋是蛋白质的重要结构元素。为了提供一个支架肽的面部识别，我们已经探讨了阳离子混合单层保护簇（MMPCs）与四天冬氨酸肽在水中的相互作用。在这些研究中，加入MMPC后观察到肽螺旋度显著增强。值得注意的是，这种稳定性随着时间的推移而增加，证明了单层对肽螺旋的模板化。
α-Helices are important structural elements in proteins. To provide a scaffold for the facial recognition of peptides, we have explored the interaction of cationic mixed monolayer protected clusters (MMPCs) with a tetra-aspartate peptide in water. In these studies, substantial enhancement of peptide helicity was observed upon addition of the MMPC. Significantly, this stabilization increased with time, demonstrating templation of the monolayer to the peptide helix.