Mind-body therapies and control of inflammatory biology: A descriptive review.
Mind-body therapies and control of inflammatory biology: A descriptive review.
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DOI：
10.1016/j.bbi.2015.06.012
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Irwin MR
中科院分区：
文献类型：
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作者：
Bower JE;Irwin MR
近年来，包括太极、气功、瑜伽和冥想在内的身心疗法的使用稳步增长。这些方法已被证明在减轻症状和改善生活质量方面是有效的，研究已经开始检查这些疗法对包括炎症在内的生物过程的影响。对26个随机对照试验进行了回顾，以描述心身疗法（mbt）对循环、细胞和基因组炎症标志物的影响。这一定性评价显示，mbt对循环炎症标志物（包括CRP和IL-6）以及刺激的细胞因子产生的测量有不同的影响。基因组标记的研究结果更为一致，试验显示炎症相关基因的表达减少，通过促炎转录因子NF-κB的信号传导减少。讨论了这些影响的潜在机制，包括神经内分泌、神经、心理和行为过程的改变。
The use of mind-body therapies, including Tai Chi, Qigong, yoga, and meditation, has grown steadily in recent years. These approaches have been shown to be effective in reducing symptoms and improving quality of life, and research has begun to examine the impact of these therapies on biological processes, including inflammation. A review of 26 randomized controlled trials was conducted to describe the effects of mind-body therapies (MBTs) on circulating, cellular, and genomic markers of inflammation. This qualitative evaluation showed mixed effects of MBTs on circulating inflammatory markers, including CRP and IL-6, and on measures of stimulated cytokine production. More consistent findings were seen for genomic markers, with trials showing decreased expression of inflammation-related genes and reduced signaling through the proinflammatory transcription factor NF-κB. Potential mechanisms for these effects are discussed, including alterations in neuroendocrine, neural, and psychological and behavioral processes.