Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis
Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis
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DOI：
10.1096/fj.00-0833hyp
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发表时间：
2001-06-01
期刊：
影响因子：
4.8
通讯作者：
Walker, WA
中科院分区：
文献类型：
--
作者：
Claud, EC;Walker, WA
新生儿坏死性小肠结肠炎（NEC）是早产儿发病的主要原因。我们假设这种疾病的肠道损伤是NEC的三个主要危险因素协同作用的结果：早产、肠内喂养和细菌定植。这些因素共同导致过度的炎症反应，导致缺血性肠坏死。母乳可能通过减少致病菌定植、促进非致病性菌群生长、促进肠道屏障成熟和改善促炎反应来降低NEC的发病率。
Neonatal necrotizing enterocolitis (NEC) is a major cause of morbidity in preterm infants. We hypothesize that the intestinal injury in this disease is a consequence of synergy among three of the major risk factors for NEC: prematurity, enteral feeding, and bacterial colonization. Together these factors result in an exaggerated inflammatory response, leading to ischemic bowel necrosis. Human milk may decrease the incidence of NEC by decreasing pathogenic bacterial colonization, promoting growth of nonpathogenic flora, promoting maturation of the intestinal barrier, and ameliorating the proinflammatory response.