Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
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DOI：
10.1016/j.schres.2007.05.041
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发表时间：
2008-01-01
影响因子：
4.5
通讯作者：
Straub, Richard E.
中科院分区：
文献类型：
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作者：
Weickert, Cynthia Shannon;Rothmond, Debora A.;Straub, Richard E.
遗传学和分子生物学研究表明，dybindin-1在精神分裂症的病理生理学中起着重要作用。我们检测了精神分裂症患者海马结构中的dybindin-1mRNA，发现在齿状颗粒和多形细胞以及在海马区CA3中表达减少，但在CA1中没有表达。此外，在精神分裂症中，dybindin-1mRNA与已知减少的突触标志物的表达呈正相关。我们的结果表明，先前报道的dybindin-1蛋白的减少可能部分是由于dybindin-1mRNA的减少，而dybindin-1的减少可能参与了精神分裂症患者海马结构的突触病理。(C)2007 Elsevier B.V.保留所有权利。
Genetic and molecular studies indicate that dysbindin-1 plays a role in the pathophysiology of schizophrenia. We examined dysbindin-1 mRNA in the hippocampal formation of patients with schizophrenia and found reduced expression in dentate granule and polymorph cells and in hippocampal field CA3, but not in CA1. Furthermore, there were positive correlations between dysbindin-1 mRNA and expression of synaptic markers known to be reduced in schizophrenia. Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia. (C) 2007 Elsevier B.V. All rights reserved.