One‐ and five‐year follow‐ups on blood pressure and renal function in kidney donors
One‐ and five‐year follow‐ups on blood pressure and renal function in kidney donors
复制标题
肾脏捐献者血压和肾功能的一年和五年随访
作者：
G. Mjøen;K. Midtvedt;I. Holme;O. Øyen;P. Fauchald;H. Bergrem;H. Holdaas
如果符合国际公认的医学标准，捐赠肾脏被认为是安全的。但也有部分捐献者在捐献后出现了高血压、蛋白尿、肾功能受损等情况。该研究基于1997-2007年期间908名献血者的回顾性数据。从患者档案和挪威活体供体登记处收集术前和随访数据。665名捐赠者在捐赠后1年和256名捐赠者在捐赠后5年的随访数据可用。 我们使用肾脏疾病饮食改良四变量方程计算了估计的肾小球滤过率（eGFR）。献血后1年和5年，高血压患病率分别为11.7%和27.1%，而献血前为2.6%。1年和5年时蛋白尿的发生率分别为3.3%和1.6%。 1年时平均eGFR为56.1 ± 10.8 ml/min/1.73 m²， 5年时为61.0 ±11.8 ml/min/1.73 m²。 献血时的平均血压为122.5 ± 10.6/76.2 ± 7.5 mmHg（n = 908），1年时为124.3± 14.2/77.9 ± 8.2 mmHg（n = 649），5年随访时为127.2± 15.4/78.8 ± 8.3 mmHg（n = 247）。 我们没有发现肾切除术后肾功能进一步下降的证据。
It is considered safe to donate a kidney if internationally accepted medical criteria are fulfilled. However, some donors have encountered hypertension, proteinuria and impaired renal function after donation. The study was based on retrospective data on 908 donors, donating in the period 1997–2007. Preoperative and follow‐up data were collected from patient files and the Norwegian Living Donor Registry. Follow‐up data were available for 665 donors at 1 year after donation, and 256 donors at 5 years after donation. We calculated the estimated glomerular filtration rate (eGFR) using the four variable Modification of Diet in Renal Disease equation. At 1 and 5 years after donation, the prevalence of hypertension was 11.7% and 27.1% respectively compared to 2.6% before donation. Proteinuria was present in 3.3% and 1.6% at 1 and 5 years. Mean eGFR was 56.1 ± 10.8 ml/min/1.73 m² at 1 year and 61.0 ± 11.8 ml/min/1.73 m² at 5 years. Mean blood pressure was 122.5 ± 10.6/76.2 ± 7.5 mmHg at donation (n = 908), 124.3 ± 14.2/77.9 ± 8.2 mmHg at 1‐year (n = 649) and 127.2 ± 15.4/78.8 ± 8.3 mmHg at 5‐year follow‐ups (n = 247). We found no evidence of further decline in renal function beyond the initial decrement following nephrectomy.
DOI：
10.2215/cjn.05280709
发表时间：
2010-03-01
影响因子：
9.8
作者：
Tan, Jane C.;Ho, Bing;Myers, Bryan D.
通讯作者：
Myers, Bryan D.