Hedscandines A -C, three undescribe dindole alkaloids from Hedyotis scandens with thei ranti-MRSA activity
Hedscandines A -C, three undescribe dindole alkaloids from Hedyotis scandens with thei ranti-MRSA activity
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DOI：
10.1016/j.phytochem.2024.113988
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Guo-Ping Yin
中科院分区：
文献类型：
--
作者：
Yu-Jun Wang;Xue Chen;Yong Yin;Wei Zhou;Pei-Fu Zhou;Ling-Gao Zeng;Chang-Hua Hu;Guo-Ping Yin
Hedscandines A-C (1-3), three undescribed indole alkaloids were isolated from Hedyotis scandens Roxb, a traditional Chinese medicine widely used in the treatment of respiratory ailments. Their structures were elucidated by extensive spectroscopic data and electronic circular dichroism (ECD) calculation. Hedscandine A (1), possessed a unique carbon skeleton with a 1,4-oxazonin-2(3H)-one core system and displayed a rapid bactericidal activity against MRSA with a MIC value of 16 μg/mL. Mechanistic studies showed that compound 1 could disrupt the integrity of bacterial cell membranes and thus lead to bacterial death.
