Emerging roles and regulation of MiT/TFE transcriptional factors.
Emerging roles and regulation of MiT/TFE transcriptional factors.
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MiT/TFE 转录因子的新作用和调控
DOI：
10.1186/s12964-018-0242-1
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发表时间：
2018-06-15
期刊：
影响因子：
--
通讯作者：
Tang B
中科院分区：
文献类型：
--
作者：
Yang M;Liu E;Tang L;Lei Y;Sun X;Hu J;Dong H;Yang SM;Gao M;Tang B
MiT/TFE转录因子在自噬和溶酶体生物发生的调控中起着关键作用。MiT/TFE蛋白的亚细胞定位和活性主要通过磷酸化调控。磷酸化蛋白保留在细胞质中，随后在去磷酸化后易位到细胞核，在那里它刺激数百个基因的表达，导致溶酶体生物发生和自噬诱导。转录因子介导的溶酶体到核信号可以由参与mTORC1、PKC和AKT通路的几个信号分子直接控制。MiT/TFE家族成员因其在细胞内清除多种疾病的致病因子而备受关注。最近，多项研究也发现MiT/TFE蛋白是细胞代谢重编程的主要调节因子，聚集在自噬和溶酶体功能上，并在癌症中发挥关键作用，这表明新的治疗策略可能基于MiT/TFE家族成员活性的调节。在此，我们就MiT/TFE转录因子及其在癌症中的潜在机制的最新研究进行综述。
The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phosphorylation. And the phosphorylated protein is retained in the cytoplasm and subsequently translocates to the nucleus upon dephosphorylation, where it stimulates the expression of hundreds of genes, leading to lysosomal biogenesis and autophagy induction. The transcription factor-mediated lysosome-to-nucleus signaling can be directly controlled by several signaling molecules involved in the mTORC1, PKC, and AKT pathways. MiT/TFE family members have attracted much attention owing to their intracellular clearance of pathogenic factors in numerous diseases. Recently, multiple studies have also revealed the MiT/TFE proteins as master regulators of cellular metabolic reprogramming, converging on autophagic and lysosomal function and playing a critical role in cancer, suggesting that novel therapeutic strategies could be based on the modulation of MiT/TFE family member activity. Here, we present an overview of the latest research on MiT/TFE transcriptional factors and their potential mechanisms in cancer.
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影响因子：
4.7
作者：
Ivankovic D;Chau KY;Schapira AH;Gegg ME
通讯作者：
Gegg ME
DOI：
10.1073/pnas.0931430100
发表时间：
2003-05-13
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Raimundo N
影响因子：
4.8
作者：
Bhatelia, Khyati;Singh, Kritarth;Singh, Rajesh
通讯作者：
Singh, Rajesh