Quantitative effect of the neonatal fontanel on synthetic near infrared spectroscopy measurements
Quantitative effect of the neonatal fontanel on synthetic near infrared spectroscopy measurements
复制标题
DOI：
10.1002/hbm.21483
复制
发表时间：
2013-04-01
影响因子：
4.8
通讯作者：
Wallois, Fabrice
中科院分区：
文献类型：
--
作者：
Dehaes, Mathieu;Kazemi, Kamran;Wallois, Fabrice
近红外光谱（NIRS）是一种功能成像技术，可以测量局部脑氧合。这种方式特别适合于危重新生儿，因为它可以在床边使用，是一个合适的和非侵入性的工具进行纵向研究。然而，NIRS对成像介质敏感，因此对光子在其中传播的生物组织的光学性质敏感。在这项研究中，通过使用概率蒙特卡罗方法预测光子传播的影响，新生儿<$门进行了调查。根据计算机断层扫描和磁共振图像创建了两个新生儿头部解剖模型：（1）包括门牙组织的真实模型和（2）门牙被颅骨组织取代的模型。针对特定激活区域和颞区模拟的光学阵列的两种模型，比较了模拟激活引起的吸收量变化。计算校正因子，以量化囟门的影响，并定义为真实变化和恢复变化之间的比率。结果表明，当用包括<$门的解剖模型确定时，吸收的恢复变化更精确。结果表明，在定量NIRS反应，以避免误解，涉及时间领域的实验，如语言或听觉研究，应考虑到<$N。^Brain Mapp，2013. (c)2011 Wiley Periodicals，Inc.
Near infrared spectroscopy (NIRS) is a functional imaging technique allowing measurement of local cerebral oxygenation. This modality is particularly adapted to critically ill neonates, as it can be used at the bedside and is a suitable and noninvasive tool for carrying out longitudinal studies. However, NIRS is sensitive to the imaged medium and consequently to the optical properties of biological tissues in which photons propagate. In this study, the effect of the neonatal fontanel was investigated by predicting photon propagation using a probabilistic Monte Carlo approach. Two anatomical newborn head models were created from computed tomography and magnetic resonance images: (1) a realistic model including the fontanel tissue and (2) a model in which the fontanel was replaced by skull tissue. Quantitative change in absorption due to simulated activation was compared for the two models for specific regions of activation and optical arrays simulated in the temporal area. A correction factor was computed to quantify the effect of the fontanel and defined by the ratio between the true and recovered change. The results show that recovered changes in absorption were more precise when determined with the anatomical model including the fontanel. The results suggest that the fontanel should be taken into account in quantification of NIRS responses to avoid misinterpretation in experiments involving temporal areas, such as language or auditory studies. Hum Brain Mapp, 2013. (c) 2011 Wiley Periodicals, Inc.