Periodontal Conditions of Individuals With Sjogren's Syndrome
Periodontal Conditions of Individuals With Sjogren's Syndrome
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DOI：
10.1902/jop.2009.080350
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发表时间：
2009-03-01
影响因子：
4.3
通讯作者：
Oppermann, Rui Vicente
中科院分区：
文献类型：
--
作者：
Antoniazzi, Raquel Pippi;Miranda, Leticia Algarves;Oppermann, Rui Vicente
背景：舍格伦综合征（Sjogren's syndrome，SjS）是一种全身性自身免疫性疾病，可导致唾液分泌减少并对口腔环境产生负面影响。关于这组受试者的牙周状况的证据仍有争议。本研究旨在评价原发性干燥综合征（SjS [P]）或继发性干燥综合征（SjS [S]）患者与对照组的牙周临床状况和龈沟液（GCF）中的炎症标志物。19名患有SIS的个人从两家私人诊所和一家医院选择了11名SjS [P]和8名SjS [S]和19名对照，性别，年龄和烟草暴露相匹配。比较各组的刺激全唾液（SWS）流速、菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）、探诊出血（BOP）、临床附着水平（CAL）、GCF中白细胞介素（IL）-1 β总量和总弹性蛋白酶活性。结果：SjS患者SWS流速显著低于对照组，PI、GI、PD、CAL和BOP均高于对照组。在调整斑块后，SjS患者的GI仍然显著较高。SjS（S）患者的平均CAL和PD显著高于SjS（P）患者，校正后该亚组的CAL和BOP仍显著较高。在GCF炎症标志物方面未观察到差异。结论：SjS对牙周健康有不良影响，尤其是SjS（S）患者，牙龈炎症更明显。J Periodon tot 2009;80：429-435.
Background: Sjogren's syndrome (SjS) is a systemic autoimmune disease that might lead to hyposalivation and negatively affect the oral environment. The evidence with regard to the periodontal conditions in this group of subjects is still controversial. This study aimed to evaluate the periodontal clinical conditions and inflammatory markers in gingival crevicular fluid (GCF) from patients with primary Sjogren's syndrome (SjS [P]) or secondary Sjogren's syndrome (SjS [S]) compared to a control group.Methods: Nineteen individuals with SiS (11 SjS [P] and eight SjS [S]) and 19 controls, matched for gender, age, and tobacco exposure, were selected from two private clinics and a hospital. The groups were compared for stimulated whole saliva (SWS) flow rate, plaque index (PI), gingival index (GI), probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and total amount of interleukin (IL)-1 beta and total elastase activity in the GCF. Generalized estimating equations were used for data analysis.Results: Individuals with SjS had a significantly lower SWS flow rate and higher mean PI, GI, PD, CAL, and BOP than controls. After adjustment for plaque, GI remained significantly higher in patients with SjS. Patients with SjS (S) had significantly higher mean CAL and PD than patients with SjS (P), and CAL and BOP remained significantly higher in this subgroup after adjustment. No differences were observed with regard to the GCF inflammatory markers. After adjusting for PD, subjects with SjS (P) showed lower levels of IL-10 compared to controls.Conclusion: SjS seemed to negatively affect the periodontal condition because gingival inflammation was more evident in the individuals with SjS, particularly those with SjS (S). J Periodon tot 2009;80:429-435.