RELATIONSHIP BETWEEN LIVER-TUMORS AND AGE IN BROWN BULLHEAD POPULATIONS FROM 2 LAKE ERIE TRIBUTARIES
RELATIONSHIP BETWEEN LIVER-TUMORS AND AGE IN BROWN BULLHEAD POPULATIONS FROM 2 LAKE ERIE TRIBUTARIES
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DOI：
10.1016/0048-9697(90)90365-2
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发表时间：
1990-05-01
影响因子：
9.8
通讯作者：
HARTMAN, KJ
中科院分区：
文献类型：
--
作者：
BAUMANN, PC;HARSHBARGER, JC;HARTMAN, KJ
我们比较了来自伊利湖两条支流的全长超过250 mm的棕色牛头(Ictalurus Neblosus)的肝脏肿瘤发生率、年龄和长度特征。从老妇人溪(n=144)采集的牛头鱼没有肉眼可见的肝脏肿瘤，而在高度工业化的黑河(n=532)采集的牛头鱼在1981-1982年间出现明显可见的肝脏肿瘤的频率为30%。从黑河随机采集的棕色牛头鱼样本(n=125)中，组织学诊断为肝脏病变的鱼包括胆管和肝脏病变，其中38.4%的鱼发生癌症。4岁和5岁的黑河牛头鱼的胆道癌患病率(35.5%)显著高于2岁和3岁的牛头鱼(18.4%)(p≤0.05)。胆道癌在4岁鱼(性别合计)和3岁和4岁男性中显著高于肝细胞癌，女性明显高于男性。两个地点的牛头鱼年龄分布差异很大，而长度分布相似。在黑河中没有收集到6岁或7岁的棕色牛头鱼，而这些年龄段的鱼占老妇人溪渔获量的18%。在老妇人溪中，5岁的棕色牛头鱼的数量几乎是黑河收藏中的六倍。这些年龄和长度分布符合这样的假设，即黑河中的棕色牛头鱼受到与肝癌高发相关的年龄选择性死亡的影响。
We compared liver tumor frequencies, and age and length characteristics of brown bullheads (Ictalurus nebulosus) of greater than 250 mm total length from two Lake Erie tributaries. Bullheads taken from Old Woman Creek (n= 144) had no grossly observable liver tumors, while those collected in the highly industrialized Black River (n= 532) had a 30% frequency of grossly visible liver tumors during 1981–1982. Liver lesions diagnosed histologically in a randomly collected sample (n= 125) of brown bullheads from the Black River included both biliary and hepatic lesions, with cancerous neoplasms occuring in 38.4% of the fish. Black River bullheads of combined ages 4 and 5 had a significantly (p≤0.05) greater prevalence of biliary carcinomas (35.5%) than those of ages 2 and 3 combined (18.4%). Biliary carcinoma was significantly more prevalent than hepatocellular carcinoma in age 4 fish (sexes combined) and in males of ages 3 and 4. The prevalence of hepatocellular carcinoma was significantly higher in females than in males. Age distributions of bullheads differed significantly between the two sites, while length distributions were similar. No brown bullheads of ages 6 or 7 were collected in the Black River, while these age groups composed 18% of the catch in Old Woman Creek. Brown bullheads of age 5 were almost six times more numerous in the Old Woman Creek than in Black River collections. These age and length distributions are consistent with the hypothesis that brown bullheads in the Black River were subjected to an age-selective mortality associated with high prevalences of liver carcinoma.