Pilot study of participant-collected nasal swabs for acute respiratory infections in a low-income, urban population
Pilot study of participant-collected nasal swabs for acute respiratory infections in a low-income, urban population
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DOI：
10.2147/clep.s95847
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发表时间：
2016-01-01
影响因子：
3.9
通讯作者：
Stockwell, Melissa S.
中科院分区：
文献类型：
--
作者：
Vargas, Celibell Y.;Wang, Liqun;Stockwell, Melissa S.
目的：为了评估的可行性和有效性，无人监督的参与者收集的鼻拭子检测呼吸道病原体在低收入，城市少数population.Methods：这个项目进行了一个正在进行的社区为基础的监测研究的一部分，在纽约市，以确定急性呼吸道感染的病毒病因。2014年1月，在经过培训的研究助理采集样本后，来自30个家庭的急性呼吸道感染受试者随后通过邮件采集并返还了自我采集/父母采集的鼻拭子。自我/父母拭子对应的阳性逆转录聚合酶链反应primary research samples进行了analysed.Results：几乎所有（96.8%，n= 30/31）的家庭同意参加，100%报告返回的样本和29收到（中位数时间：8天）。大多数（18; 62.1%）的主要研究样本呈阳性。在8份流感阳性研究样本中，7份（87.5%）自拭子也呈阳性。对于其他10份呼吸道病原体阳性研究样本，8份（80.0%）自拭子呈阳性。自拭子对任何呼吸道病原体的敏感性为83.3%，对流感的敏感性为87.5%，特异性为100%。积极的研究样本和他们匹配的参与者swab.Conclusion：在这项试点研究中，自拭子是可行的，有效的低收入，城市少数民族人口之间的教育水平和一致性的结果之间没有关系。
Objective: To assess the feasibility and validity of unsupervised participant-collected nasal swabs to detect respiratory pathogens in a low-income, urban minority population.Methods: This project was conducted as part of an ongoing community-based surveillance study in New York City to identify viral etiologies of acute respiratory infection. In January 2014, following sample collection by trained research assistants, participants with acute respiratory infection from 30 households subsequently collected and returned a self-collected/parent-collected nasal swab via mail. Self/parental swabs corresponding with positive reverse transcription polymerase chain reaction primary research samples were analyzed.Results: Nearly all (96.8%, n= 30/31) households agreed to participate; 100% reported returning the sample and 29 were received (median time: 8 days). Most (18; 62.1%) of the primary research samples were positive. For eight influenza-positive research samples, seven (87.5%) self-swabs were also positive. For ten other respiratory pathogen-positive research samples, eight (80.0%) self-swabs were positive. Sensitivity of self-swabs for any respiratory pathogen was 83.3% and 87.5% for influenza, and specificity for both was 100%. There was no relationship between level of education and concordance of results between positive research samples and their matching participant swab.Conclusion: In this pilot study, self-swabbing was feasible and valid in a low-income, urban minority population.