Association between the relative abundance of gastric microbiota and the risk of gastric cancer: a case-control study
Association between the relative abundance of gastric microbiota and the risk of gastric cancer: a case-control study
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DOI：
10.1038/s41598-019-50054-x
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发表时间：
2019-09-19
影响因子：
4.6
通讯作者：
Kim, Jeongseon
中科院分区：
文献类型：
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作者：
Gunathilake, Madhawa Neranjan;Lee, Jeonghee;Kim, Jeongseon
人类肠道中有一个多样化的细菌群落，称为肠道微生物组。我们调查了韩国人群中胃微生物群的相对丰度与胃癌（GC）风险之间的关系。研究参与者包括268名胃癌患者和288名对照。从胃活检组织中提取DNA，并进行16 S rRNA基因分析。非条件Logistic回归模型用于观察相关性。在参与者中，那些拥有最高水平的人在调整潜在的混杂变量后，相对幽门螺杆菌和痤疮丙酸杆菌丰度（最高三分位数）显示出显著更高的GC风险。（比值比（OR）= 1.86，95%置信区间（CI）= 1.17-2.97，趋势p = 0.017和OR = 4.77，95%CI = 2.94-7.74，趋势p < 0.001）。携带犬普雷沃氏菌的受试者发生GC的风险显著高于非携带者（OR = 2.54，95%CI = 1.42-4.55，趋势p = 0.002）。携带乳酸乳球菌的受试者发生GC的风险低于非携带者（OR = 0.21，95%CI = 0.10-0.44，p < 0.001）。H. pylori、痤疮丙酸杆菌和鸡眼丙酸杆菌是较强的危险因素，而L. lactis是韩国人GC发育的保护因子。需要进一步的微生物组研究来验证当前研究的结果。
The human gut hosts a diverse community of bacteria referred to as the gut microbiome. We investigated the association between the relative abundance of gastric microbiota and gastric cancer (GC) risk in a Korean population. The study participants included 268 GC patients and 288 controls. DNA was extracted from gastric biopsies, and 16S rRNA gene analysis was performed. Unconditional logistic regression models were used to observe the associations. Of the participants, those who had the highest level (highest tertile) of relative Helicobacter pylori and Propionibacterium acnes abundances showed a significantly higher risk for GC after adjusting for potential confounding variables (odds ratio (OR) = 1.86, 95% confidence interval (CI) = 1.17-2.97, p for trend = 0.017 and OR = 4.77, 95% CI = 2.94-7.74, p for trend < 0.001, respectively). Subjects who carried Prevotella copri had a significantly higher risk of GC than noncarriers (OR = 2.54, 95% CI = 1.42-4.55, p for trend = 0.002). There was a lower risk of GC in subjects carrying Lactococcus lactis than in noncarriers (OR = 0.21, 95% CI = 0.10-0.44, p for trend < 0.001). H. pylori, P. acnes and P. copri are strong risk factors, whereas L. lactis is a protective factor, for GC development in Koreans. Further microbiome studies are warranted to verify the findings of the current study.