Gambling disorder: an integrative review of animal and human studies.
Gambling disorder: an integrative review of animal and human studies.
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DOI：
10.1111/nyas.13356
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发表时间：
2017-04
影响因子：
5.2
通讯作者：
Blanco C
中科院分区：
文献类型：
--
作者：
Nautiyal KM;Okuda M;Hen R;Blanco C
赌博障碍（GD），以前被称为病理性赌博，在DSM-III和DSM-IV中被归类为冲动控制障碍，最近在DSM-5中被重新归类为成瘾性障碍。它被广泛认为是一个重要的公共卫生问题，与大量的个人和社会成本，精神并发症的高发病率，身体健康状况差，自杀率升高。已经确定了一些风险因素，包括一些遗传多态性。已经开发了动物模型以研究GD的潜在神经基础。在这里，我们讨论我们的风险因素，病程和病理生理学的理解的最新进展。一个集中在一个表型为基础的解剖疾病包括已知的神经相关的动物和人类的研究进行审查。最后，目前的治疗方法进行了讨论，以及未来的GD研究方向。
Gambling disorder (GD), previously called pathological gambling and classified as an impulse control disorder in DSM-III and DSM-IV, has recently been reclassified as an addictive disorder in the DSM-5. It is widely recognized as an important public health problem associated with substantial personal and social costs, high rates of psychiatric comorbidity, poor physical health, and elevated suicide rates. A number of risk factors have been identified, including some genetic polymorphisms. Animal models have been developed in order to study the underlying neural basis of GD. Here, we discuss recent advances in our understanding of the risk factors, disease course, and pathophysiology. A focus on a phenotype-based dissection of the disorder is included in which known neural correlates from animal and human studies are reviewed. Finally, current treatment approaches are discussed, as well as future directions for GD research.