DEET repels ORNery mosquitoes
DEET repels ORNery mosquitoes
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DEET 可驱除 ORNery 蚊子
DOI：
10.1073/pnas.0807167105
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
J. Logan
中科院分区：
文献类型：
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作者：
J. Pickett;M. Birkett;J. Logan
避蚊胺（[N-N]-二乙基间甲苯酰胺）在世界各地广泛用作蚊子和其他叮咬昆虫的驱避剂。它最初是通过使用合成化合物的结构-活性研究来鉴定的 (1)。最近，已鉴定出许多具有类似活性的新化合物 [例如派卡瑞定 (2)]，但避蚊胺仍然是金标准。然而，尽管进行了大量研究 (3)，避蚊胺的作用的合理且基于证据的机制仍然难以捉摸。在最近的一项研究中，Ditzen 等人。 (4) 写道，“在这里，我们证明避蚊胺会阻断冈比亚按蚊和黑腹果蝇嗅觉感觉神经元对诱人气味的电生理反应”（图 1A）。然而，在本期《PNAS》中，Syed 和 Leal (5) 提出了一种新机制，证明蚊子通过嗅觉检测避蚊胺，这是它们回避行为的直接原因（图 1B）。
DEET ([N-N]-diethyl-m-toluamide) is widely used around the world as a repellent for mosquitoes and other biting insects. It was originally identified by a structure–activity study using synthetic compounds (1). Recently, a number of new compounds with similar activity [e.g., picaridine (2)] have been identified, but DEET remains the gold standard. Despite a tremendous number of studies (3), however, a plausible and evidence-based mechanism for DEET's action has remained elusive. In a recent study, Ditzen et al. (4) wrote, “Here we show that DEET blocks electrophysiological responses to olfactory sensory neurons to attractive odors in Anopheles gambiae and Drosophila melanogaster” (Fig. 1A). However, in this issue of PNAS, Syed and Leal (5) present a new mechanism that demonstrates that mosquitoes detect DEET by means of olfaction and that this is the direct cause of their avoidance behavior (Fig. 1B).