Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota
Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota
复制标题
对大量人类肠道微生物群中抗生素抗性基因进行宏基因组分析
DOI：
10.1038/ncomms3151
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发表时间：
2013-07-01
影响因子：
16.6
通讯作者：
Zhu, Baoli
中科院分区：
文献类型：
--
作者：
Hu, Yongfei;Yang, Xi;Zhu, Baoli
人类肠道微生物群是抗生素耐药基因的储存库，但对它们在肠道内的多样性和丰富性知之甚少。在这里，我们分析了来自162个个体的肠道微生物群的抗生素耐药基因。我们总共鉴定了1,093个抗生素耐药基因，发现中国人携带的抗生素耐药基因数量和丰度最高，其次是丹麦人和西班牙人。基于单核苷酸多态性的分析表明，来自两个欧洲人群的抗生素耐药基因的关系更为密切，而中国人的聚类分开。我们还证实了高丰度的四环素耐药基因与这个大的队列研究。我们的研究为人类肠道微生物群中的抗生素耐药基因提供了广泛的视角。
The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.