Prevalence and classification of mild cognitive impairment in the cardiovascular health study cognition study part 1
Prevalence and classification of mild cognitive impairment in the cardiovascular health study cognition study part 1
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DOI：
10.1001/archneur.60.10.1385
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发表时间：
2003-10-01
影响因子：
--
通讯作者：
Kuller, LH
中科院分区：
文献类型：
--
作者：
Lopez, OL;Jagust, WJ;Kuller, LH
目的：在心血管健康研究（CHS）认知研究中检查轻度认知障碍（MCI）的患病率及其诊断分类。设计：CHS认知研究是CHS的辅助研究，旨在确定CHS队列中MCI和痴呆的存在。设置：多中心人群研究。患者：我们对3608名CHS参与者进行了详细的神经学、神经心理学、神经放射学和精神病学测试，以确定痴呆和MCI。MCI的患病率确定为整个队列，MCI的特定亚型仅在宾夕法尼亚州匹兹堡中心进行详细检查（n=927）。轻度认知功能障碍分为MCI遗忘型或MCI多认知缺陷型。结果：MCI的总患病率为19%（465/2470），患病率随着年龄的增长而增加，从75岁以下的19%增加到85岁以上的29%。匹兹堡中心MCI的总患病率为22%（130/599例参与者）; MCI遗忘型的患病率为6%，MCI多认知缺陷型的患病率为16%。轻度认知功能障碍是一种异质性综合征，其中MCI遗忘型比MCI多重认知缺陷型更不常见。大多数MCI参与者患有可能影响其认知功能的共病。
Objective: To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study.Design: The CHS Cognition Study is an ancillary study of the CHS that was conducted to determine the presence of MCI and dementia in the CHS cohort.Setting: Multicenter population study.Patients: We examined 3608 participants in the CHS who had undergone detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI.Main Outcome Measures: The prevalence of MCI was determined for the whole cohort, and specific sub-types of MCI were examined in detail only at the Pittsburgh, Pa, center (n=927). Mild cognitive impairment was classified as either MCI amnestic-type or MCI multiple cognitive deficits-type.Results: The overall prevalence of MCI was 19% (465 of 2470 participants) prevalence increased with age from 19% in participants younger than 75 years to 29% in those older than 85 years. The overall prevalence of MCI at the Pittsburgh center was 22% (130 of 599 participants); prevalence of the MCI amnesic-type was 6% and of the MCI multiple cognitive deficits-type was 16%.Conclusions: Twenty-two percent of the participants aged 75 years or older had MCI. Mild cognitive impairment is a heterogenous syndrome, where the MCI amnestic-type is less frequent than the MCI multiple cognitive deficits-type. Most of the participants with MCI had comorbid conditions that may affect their cognitive functions.