Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes
Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes
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DOI：
10.1093/humrep/dei080
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发表时间：
2005-09-01
影响因子：
6.1
通讯作者：
Foster, WG
中科院分区：
文献类型：
--
作者：
Neal, MS;Hughes, EG;Foster, WG
背景：吸烟（CS）是一种公认的健康危害，但它在社会中仍然普遍存在，环境烟草烟雾暴露对生育的影响尚不清楚。我们的目的是测量CS对主流（MS）或侧流（SS）吸烟妇女与非吸烟妇女生育能力的影响。方法：本回顾性研究调查了225例接受IVF （n=97）或ICSI （n=128）的女性患者。根据患者的吸烟状况进行分组进行比较。其中包括：39例MS(18例IVF和21例ICSI)；40例SS （IVF 16例，ICSI 24例）；146名NS（63名IVF和83名ICSI）妇女。生育治疗结果包括胚胎质量、着床率和妊娠率。结果：三组胚胎质量无明显差异。然而，每次胚胎移植的着床率（MS=12.0%， SS=12.6%， NS=25.0%）和妊娠率（MS=19.4%， SS=20.0%， NS=48.3%）差异有统计学意义。结论：尽管胚胎质量相似，但MS吸烟者和SS吸烟者的着床率和妊娠率与NS吸烟者相比有显著差异。我们的数据表明，吸烟对生育能力的影响与吸烟对生育能力的损害是一样的。
BACKGROUND: Cigarette smoking (CS) is a widely recognized health hazard, yet it remains prevalent in society and the effects of environmental tobacco smoke exposure on fertility are unknown. Our objective was to measure the effects of CS on the fertility of mainstream (MS) or sidestream (SS) smoke-exposed women compared to their non-smoking (NS) counterparts. METHODS: This retrospective study investigated 225 female patients undergoing IVF (n=97) or ICSI (n=128). Patients were grouped based on their smoking status for comparison. This included: 39 MS (18 IVF and 21 ICSI); 40 SS (16 IVF and 24 ICSI); and 146 NS (63 IVF and 83 ICSI) women. Fertility treatment outcomes including embryo quality, implantation and pregnancy rate were measured. RESULTS: No difference in embryo quality between the three groups was observed. However, there was a significant difference in implantation rate (MS=12.0%, SS=12.6%, and NS=25.0%) and pregnancy rate (MS=19.4%, SS=20.0%, and NS=48.3%) per embryo transfer. CONCLUSIONS: Despite similar embryo quality there was a striking difference in implantation and pregnancy rates of MS and SS smokers when compared with NS. Our data demonstrate that the effects of SS smoking are equally as damaging as MS smoke on fertility.