Interaction between phenanthrene and zinc in their toxicity to the sheepshead minnow (Cyprinodon variegatus)
Interaction between phenanthrene and zinc in their toxicity to the sheepshead minnow (Cyprinodon variegatus)
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DOI：
10.1007/s002449900512
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发表时间：
1999-08-01
影响因子：
4
通讯作者：
Haas, CN
中科院分区：
文献类型：
--
作者：
Moreau, CJ;Klerks, PL;Haas, CN
许多受污染的场地含有各种有毒物质。因此，风险评估和水质标准的制定需要关于此类混合物中有毒物质之间相互作用的信息。金属之间的相互作用研究得相对较好，但对金属和碳氢化合物之间的相互作用知之甚少。以7日龄杂色丽鱼（Cyprinodon variegatus）为材料，采用96 h生物测定法，研究了菲与锌在固定比例和不同比例下的相互作用。采用毒性单位法、相加指数法和超额函数法对混合物毒性进行了定量分析。所有这三种方法通常表明菲和锌之间的拮抗作用，虽然结果也提供了一些证据，在低毒性水平或在特定的菲锌比的协同作用。进行了短期吸收实验，以确定是否强烈的拮抗作用时，锌和菲的LC 50值的50%，是由于锌和菲对彼此的吸收的影响。显着减少Zn-65的吸收发生在菲的存在下，比在其缺席。与此相反，锌似乎没有影响C-14-菲的吸收。
Many contaminated sites contain a variety of toxicants. Risk assessment and the development of water quality criteria therefore require information on the interactive effects among toxicants in such mixtures. Interactions between metals are relatively well studied, but little is known about interactions between metals and hydrocarbons. This study investigated the interaction between phenanthrene and zinc in the sheepshead minnow Cyprinodon variegatus.Interaction studies were performed with 7-day-old minnows in 96-h bioassays with zinc and phenanthrene at a fixed ratio and with varying proportions of zinc and phenanthrene. Mixture toxicity was quantified with the toxic unit, additive index, and excess function methods. All three methods generally indicated an antagonistic interaction between phenanthrene and zinc, though the results also provide some evidence for a synergistic interaction at low toxicant levels or at specific phenanthrene-to-zinc ratios. Short-term uptake experiments were conducted to determine if the strong antagonistic interaction observed when zinc and phenanthrene were present at 50% of their LC50 values was due to effects of zinc and phenanthrene on each other's uptake. Significantly less Zn-65 uptake occurred in the presence of phenanthrene than in its absence. In contrast, zinc did not appear to affect the uptake of C-14-phenanthrene.