Palladium-catalyzed alkylation of sp2 and sp3 C-H bonds with methylboroxine and alkylboronic acids:: Two distinct C-H activation pathways
Palladium-catalyzed alkylation of sp2 and sp3 C-H bonds with methylboroxine and alkylboronic acids:: Two distinct C-H activation pathways
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DOI：
10.1021/ja0646747
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发表时间：
2006-10-04
影响因子：
15
通讯作者：
Yu, Jin-Quan
中科院分区：
文献类型：
--
作者：
Chen, Xiao;Goodhue, Charles E.;Yu, Jin-Quan
钯催化的sp2和sp 3C-H键与甲基环硼氧烷或烷基硼酸的烷基化反应被开发出来。Ag 2 O或AgCO 3被用作金属转移步骤的关键氧化剂和促进剂。醚、酯、醇和烯烃官能团是容许的。一个新的C-H活化途径不同的环化过程中阐明使用甲基环硼氧烷作为耦合伴侣。
Palladium-catalyzed alkylations of sp2and sp3C−H bonds with either methylboroxine or alkylboronic acids were developed. Ag2O or AgCO3is used as a crucial oxidant and promoter for the transmetalation step. Ether, ester, alcohol, and alkene functional groups are tolerated. A new C−H activation pathway differing from the cyclometalation process is elucidated using methylboroxine as the coupling partner.