Resting state functional connectivity in early blind humans.
Resting state functional connectivity in early blind humans.
复制标题
DOI：
10.3389/fnsys.2014.00051
复制
发表时间：
2014
影响因子：
3
通讯作者：
Raichle ME
中科院分区：
文献类型：
--
作者：
Burton H;Snyder AZ;Raichle ME
在早期盲人(EB)中的基于任务的神经成像研究表明，视觉皮质对非视觉范例的反应增强。EB先前的几项功能连接性研究表明，改变的连接与这些基于任务的结果一致。但这些研究一般没有考虑到行为适应对通常在EB中观察到的终身失明的影响。EB中显示出的增强的认知能力包括更好的连续回忆和对记忆的注意。在这里，我们解决的问题是，大脑内在活动在多大程度上反映了EB的这种适应。我们进行了一项静息状态的功能磁共振成像研究，将14名EB患者与14名年龄/性别匹配的正常视力对照组(NS)进行对比。一个主要的发现是，在视觉皮质和通常与记忆和注意力认知控制相关的区域之间，EB的功能连接明显增强。相比之下，EB患者的视觉皮质和非剥夺感觉皮质之间的相关性明显较低。因此，现有的数据，包括先前基于任务和静息状态的fMRI研究的数据，以及目前的结果，表明EB中的视觉皮质更多地被整合到实例化情节回忆和对非视觉事件的注意的功能系统中。此外，EB似乎显示视觉和非剥夺感觉皮质之间的相互作用减少，可能反映了感觉间分心活动的抑制。
Task-based neuroimaging studies in early blind humans (EB) have demonstrated heightened visual cortex responses to non-visual paradigms. Several prior functional connectivity studies in EB have shown altered connections consistent with these task-based results. But these studies generally did not consider behavioral adaptations to lifelong blindness typically observed in EB. Enhanced cognitive abilities shown in EB include greater serial recall and attention to memory. Here, we address the question of the extent to which brain intrinsic activity in EB reflects such adaptations. We performed a resting-state functional magnetic resonance imaging study contrasting 14 EB with 14 age/gender matched normally sighted controls (NS). A principal finding was markedly greater functional connectivity in EB between visual cortex and regions typically associated with memory and cognitive control of attention. In contrast, correlations between visual cortex and non-deprived sensory cortices were significantly lower in EB. Thus, the available data, including that obtained in prior task-based and resting state fMRI studies, as well as the present results, indicate that visual cortex in EB becomes more heavily incorporated into functional systems instantiating episodic recall and attention to non-visual events. Moreover, EB appear to show a reduction in interactions between visual and non-deprived sensory cortices, possibly reflecting suppression of inter-sensory distracting activity.