Laws of biology: why so few?
Laws of biology: why so few?
复制标题
生物学定律：为什么这么少？
DOI：
10.1007/s11693-009-9049-0
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发表时间：
2010-03
期刊：
影响因子：
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通讯作者：
Giuliani, Alessandro
中科院分区：
文献类型：
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作者：
Dhar, Pawan K;Giuliani, Alessandro
寻找基本的组织原则是目前系统生物学的前沿知识。从一个氢原子到整个细胞水平，生物体在几个数量级的大小上管理着大规模并行和大规模互动的过程。为了管理这种规模的信息复杂性，很自然地期望确定更高层次行为的组织原则。目前，这种组织原则只是一种暗示，而没有绝对的证据。在这里，我们提出了一种与孟德尔一样古老的方法，可以帮助揭示生物学中的基本组织原则。我们的方法基本上包括确定常数在各个级别和编织成一个层次的底盘。随着我们识别和组织常数，从成对相互作用到网络，我们对生物学基本原理的理解将得到改善，从而形成生物学理论。
Finding fundamental organizing principles is the current intellectual front end of systems biology. From a hydrogen atom to the whole cell level, organisms manage massively parallel and massively interactive processes over several orders of magnitude of size. To manage this scale of informational complexity it is natural to expect organizing principles that determine higher order behavior. Currently, there are only hints of such organizing principles but no absolute evidences. Here, we present an approach as old as Mendel that could help uncover fundamental organizing principles in biology. Our approach essentially consists of identifying constants at various levels and weaving them into a hierarchical chassis. As we identify and organize constants, from pair-wise interactions to networks, our understanding of the fundamental principles in biology will improve, leading to a theory in biology.