LASER-INDUCED PRIMATE GLAUCOMA .1. PROGRESSION OF CUPPING
LASER-INDUCED PRIMATE GLAUCOMA .1. PROGRESSION OF CUPPING
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DOI：
10.1001/archopht.1984.01040031373030
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
GASSTERLAND, DE
中科院分区：
文献类型：
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作者：
PEDERSON, JE;GASSTERLAND, DE
应用Ar激光光凝治疗15只猴眼小梁网，诱导持续眼内压升高。导致IOP大幅度波动。治疗后的角镜检查显示一个开放的角和分散的低周围前粘连。视盘拔火罐在压力升高期间进展，首先表现为视神经头和乳头周围组织的后弯。在自发的IOP正常化过程中，有8只眼睛出现了早期拔罐的逆转。在大多数人看来，当火罐从碟子演变成更深的杯子时，杯子仍然是圆的。4眼伴神经纤维层缺损，眼球杯向颞下缘局灶性倾斜。在IOP升高时间延长的5例患者中，出现了全拔火罐和边缘破坏。激光诱导的灵长类青光眼具有与人类青光眼相似的特点，是研究视神经头拔罐的有效模型。
Sustained intraocular pressure [IOP] elevations were induced in 15 monkey eyes by Ar laser photocoagulation of the trabecular meshwork. Large fluctuations of IOP resulted. Posttreatment gonioscopy revealed an open angle with scattered low peripheral anterior synechiae. Optic disc cupping progressed during pressure elevations, manifested first as posterior bowing of the optic nerve head and peripapillary tissues. Reversal of this early phase of cupping occurred in eight eyes during spontaneous normalization of IOP. In most eyes, as cupping evolved from saucerization to a deeper cup, the cup remained round. In 4 eyes, focal sloping of the cup to the inferotemporal rim occurred with nerve fiber layer defects. Total cupping with undermining of the rim occurred in five yes with prolonged IOP elevation. Laser-induced primate glaucoma has features in common with juvenile human glaucoma and is a useful model for the study of cupping of the optic nerve head.