The Qatar Biobank: background and methods
The Qatar Biobank: background and methods
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DOI：
10.1186/s12889-015-2522-7
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发表时间：
2015-12-03
影响因子：
4.5
通讯作者：
Elliott, Paul
中科院分区：
文献类型：
--
作者：
Al Kuwari, Hanan;Al Thani, Asma;Elliott, Paul
背景：卡塔尔生物库旨在收集多达60,000名卡塔尔国民和长期居民(在卡塔尔居住15岁的个人)的广泛生活方式、临床和生物信息，对这些人进行长期跟踪，记录任何后续疾病，从而研究卡塔尔人口中疾病的原因、发展和疾病负担。方法：在2012年12月11日至2014年2月20日期间，1209名参与者参加了卡塔尔生物库的试点研究。在招募时，从每个参与者那里收集了广泛的表型信息，包括社会人口因素、普遍健康状况、饮食、生活方式、人体测量、身体成分、骨骼健康、认知功能、握力、视网膜成像、全身双能X射线吸收测量以及心血管和呼吸功能测量的信息/测量。血液、尿液和唾液被收集并储存起来，以供未来研究使用。一组66个临床生物标志物在所有参与者的新鲜血液样本上进行了常规测量。今后将逐步提高征兵率，扩大征兵基数，以实现广泛代表合格卡塔尔人口的一批经同意的个人。此外，计划在队列的子样本中增加额外的测量，包括脑、心脏和腹部的磁共振成像(MRI)。结果：在基线招募访问中，从每个参与者收集广泛的表型信息和生物样本的平均时间为179分钟。1209名试点研究参与者(506名男性和703名女性)年龄在28-80岁(中位数39岁)之间；899人(74.4%)是卡塔尔国民，310人(25.6%)是长期居民。大约三分之二的试点参与者受过研究生或以上的教育。结论：试点已经证明，在卡塔尔生物库项目中招募志愿者，并对行为、身体和临床特征进行密集的基线测量，是很好地接受的，并且在逻辑上是可行的。卡塔尔生物库将提供一个强大的资源，以调查卡塔尔健康状况不佳和幸福的主要决定因素，为该国目前和未来面临的公共卫生负担提供宝贵的见解。
Background: The Qatar Biobank aims to collect extensive lifestyle, clinical, and biological information from up to 60,000 men and women Qatari nationals and long-term residents (individuals living in the country for >= 15 years) aged >= 18 years (approximately one-fifth of all Qatari citizens), to follow up these same individuals over the long term to record any subsequent disease, and hence to study the causes and progression of disease, and disease burden, in the Qatari population.Methods: Between the 11th-December-2012 and 20th-February-2014, 1209 participants were recruited into the pilot study of the Qatar Biobank. At recruitment, extensive phenotype information was collected from each participant, including information/measurements of socio-demographic factors, prevalent health conditions, diet, lifestyle, anthropometry, body composition, bone health, cognitive function, grip strength, retinal imaging, total body dual energy X-ray absorptiometry, and measurements of cardiovascular and respiratory function. Blood, urine, and saliva were collected and stored for future research use. A panel of 66 clinical biomarkers was routinely measured on fresh blood samples in all participants. Rates of recruitment are to be progressively increased in the coming period and the recruitment base widened to achieve a cohort of consented individuals broadly representative of the eligible Qatari population. In addition, it is planned to add additional measures in sub-samples of the cohort, including Magnetic Resonance Imaging (MRI) of the brain, heart and abdomen.Results: The mean time for collection of the extensive phenotypic information and biological samples from each participant at the baseline recruitment visit was 179 min. The 1209 pilot study participants (506 men and 703 women) were aged between 28-80 years (median 39 years); 899 (74.4 %) were Qatari nationals and 310 (25.6 %) were long-term residents. Approximately two-thirds of pilot participants were educated to graduate level or above.Conclusions: The pilot has proven that recruitment of volunteers into the Qatar Biobank project with intensive baseline measurements of behavioural, physical, and clinical characteristics is well accepted and logistically feasible. Qatar Biobank will provide a powerful resource to investigate the major determinants of ill-health and well-being in Qatar, providing valuable insights into the current and future public health burden that faces the country.