Epstein-Barr virus-positive diffuse large B cell lymphoma, not otherwise specified, carrying a t(19;22)(q13;q11) translocation.
Epstein-Barr virus-positive diffuse large B cell lymphoma, not otherwise specified, carrying a t(19;22)(q13;q11) translocation.
复制标题
Epstein-Barr 病毒阳性弥漫性大 B 细胞淋巴瘤，未另有说明，携带 t(19;22)(q13;q11) 易位。
DOI：
10.1007/s00277-019-03898-2
复制
发表时间：
2020
期刊：
影响因子：
3.5
通讯作者：
Kimura S.
中科院分区：
文献类型：
--
作者：
Yamaguchi K;Kubota Y;Kishimori C;Ohno H;Kidoguchi K;Kizuka-Sano H;Nishioka A;Katsuya H;Ando T;Kimura S.
尊敬的编辑，易位t（19; 22）（q13; q11）在恶性血液病中很少见，这种染色体异常的意义尚不清楚。在这里，我们报告了第一例EB病毒（EBV）阳性弥漫性大B细胞淋巴瘤（DLBCL），未另行说明（NOS），t（19; 22）（q13; q11）一位74岁男性，因间歇性出现瘙痒性丘疹性病变而到皮肤科门诊就诊，因咽喉痛、舌溃疡和淋巴结（LN）肿胀而入院。体格检查显示颈部、腋窝和腹股沟淋巴结肿胀，无“B”症状。实验室检查显示LDH（350 IU/L）和sIL-2 R（1584 U/mL）水平升高。18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描显示口咽部和多个LN中的高代谢病变以及几个皮肤病变。对右腋窝淋巴结活检标本的组织学检查显示淋巴瘤细胞弥漫性增殖，核大，具有中心母细胞特征（图1a）。免疫组化显示肿瘤细胞CD 20、CD 79 a、CD 30和MUM 1阳性，CD 10和BCL 6阴性，提示非生殖中心B细胞来源。EBV编码的小RNA原位杂交和EBV潜伏膜蛋白均为阳性，
Dear Editor, Translocation t (19; 22)(q13; q11) is rare in hematological malignancies, and the significance of this chromosomal abnormality is unknown. Here, we report the first case of Epstein-Barr virus (EBV)–positive diffuse large B cell lymphoma (DLBCL), not otherwise specified (NOS), with t (19; 22)(q13; q11).A 74-year-old man, attending a dermatology out-patient clinic for intermittently occurring itchy erythematous papular lesions, was admitted to our hospital because of sore throat, tongue ulcers, and lymph node (LN) swelling. Physical examination showed LN swelling of the cervical, axillary, and inguinal LNs without “B” symptoms. Laboratory examination revealed elevated levels of LDH (350 IU/L) and sIL-2R (1584 U/mL). 18F-fluorodeoxyglucose positron emission tomography/computed tomography showed hypermetabolic lesions in the oropharynx and multiple LNs, as well as several skin lesions. Histopathological examination of a biopsy specimen from the right axillary LN showed diffuse proliferation of lymphoma cells with large nuclei and centroblastic features (Fig. 1a). Immunohistochemistry revealed that the neoplastic cells were positive for CD20, CD79a, CD30, and MUM1, and negative for CD10 and BCL6, suggesting a non-germinal center B cell origin. Both EBV-encoded small RNA in situ hybridization and EBV latent membrane protein were positive,