Circulating proteomic patterns in AF related left atrial remodeling indicate involvement of coagulation and complement cascade
Circulating proteomic patterns in AF related left atrial remodeling indicate involvement of coagulation and complement cascade
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DOI：
10.1371/journal.pone.0198461
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发表时间：
2018-11-29
期刊：
影响因子：
3.7
通讯作者：
Bollmann, Andreas
中科院分区：
文献类型：
--
作者：
Kornej, Jelena;Buettner, Petra;Bollmann, Andreas
研究背景心房颤动（AF）患者左心房（LA）电解剖重构和内径增大提示疾病进展，并与治疗效果差相关。此外，AF导致高凝状态，这反过来又促进了实验环境中AF底物的形成和疾病进展。本研究的目的是确定与左心房重构AF patients using untargeted proteomics approach.MethodsPeripheral blood samples of 48 patients（62 +/- 10 years，63%的男性，59%的持续性AF）接受AF导管消融消融术前收集的途径。23例左心房低电压区（LVA）患者，定义为
BackgroundLeft atrial (LA) electro-anatomical remodeling and diameter increase in atrial fibrillation (AF) indicates disease progression and is associated with poor therapeutic success. Furthermore, AF leads to a hypercoagulable state, which in turn promotes the development of a substrate for AF and disease progression in the experimental setting. The aim of this study was to identify pathways associated with LA remodeling in AF patients using untargeted proteomics approach.MethodsPeripheral blood samples of 48 patients (62 +/- 10 years, 63% males, 59% persistent AF) undergoing AF catheter ablation were collected before ablation. 23 patients with left atrial low voltage areas (LVA), defined as