REDUCTION OF BILE PIGMENTS BY FECAL AND INTESTINAL BACTERIA
REDUCTION OF BILE PIGMENTS BY FECAL AND INTESTINAL BACTERIA
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DOI：
10.1016/0304-4165(72)90119-5
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
NICHOLSON, DC
中科院分区：
文献类型：
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作者：
FAHMY, K;GRAY, CH;NICHOLSON, DC
1.1.研究了肠道和粪便细菌对胆色素的作用，以阐明胆红素在肠道转化为尿胆素原的模式。将胆绿素、游离和结合胆红素、中胆红素、中胆红素、天然和“合成“i-尿胆素、（+）-尿胆素和（−）-粪胆素与细菌一起孵育。3.3.来自人类粪便的混合微生物对胆绿素没有影响，但将游离和结合胆红素、天然（+）- andi-urobilin和（−）-stercobilin还原为（−）-stercobilinogen，但将中胆红素还原为（+）-和（+）-urobilins的混合物。他们将中胆素还原为一种结构未知的非尿胆素色素的色原。天然G62梭菌将游离胆红素和结合胆红素还原为粪胆素原，此作用与大肠杆菌协同。这些微生物的总超声处理减少了游离胆红素，但未将结合胆红素减少为粪胆素原。超声处理的颗粒部分无效;上清液将游离胆红素转化为非尿胆素色原，但对结合胆红素或中胆红素无影响。5.5.这些结果进行了讨论与相关的复杂性的尿胆素和乙烯基不饱和对胆色素减少的影响。
1.1. The action of intestinal and faecal bacteria on bile pigments was studied for elucidation of the mode of intestinal conversion of bilirubin to urobilinogen.2.2. Biliverdin, free and conjugated bilirubin, mesobilirubin, mesobiliviolin, natural and “synthetic”i-urobilins, (+)-urobilin and (−)-stercobilin were incubated with the bacteria.3.3. Mixed organisms from human faeces had no effect on biliverdin but reduced free and conjugated bilirubin, natural (+)- andi-urobilin and (−)-stercobilin to (−)-stercobilinogen but mesobilirubin to a mixture ofi- and (+)-urobilins. They reduced mesobiliviolin to the chromogen of a non-urobilinoid pigment of unknown structure.4.4. Natural G62 Clostridia reduced free and conjugated bilirubin to stercobilinogen, this action being synergised byEscherichia coli. Total sonicate of these organisms reduced free bilirubin but not conjugated bilirubin to stercobilinogen. The particulate fraction of the sonicate was ineffective; the supernatant converted free bilirubin to a non-urobilinoid chromogen but had no effect on conjugated bilirubin or mesobilirubin.5.5. These results are discussed with relevance to complexity of the urobilins and the effect of vinylic unsaturation on bile pigment reduction.