Influence of Induction of Hepatic Microsomal Enzymes by Phenobarbital on Toxicity of Organic Phosphate Insecticides∗
Influence of Induction of Hepatic Microsomal Enzymes by Phenobarbital on Toxicity of Organic Phosphate Insecticides∗
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苯巴比妥诱导肝微粒体酶对有机磷酸酯杀虫剂毒性的影响*
DOI：
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发表时间：
1968
期刊：
影响因子：
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通讯作者：
F. Kinoshita
中科院分区：
文献类型：
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作者：
K. P. Dubois;F. Kinoshita
总结比较了15种胆碱能有机磷酸酯对正常大鼠和小鼠以及用苯巴比妥预处理5天的动物的毒性。本研究的目的是确定苯巴比妥引起的肝微粒体酶诱导是否改变了有机磷酸盐的急性毒性。该研究表明，苯巴比妥处理降低了任何化合物在两个物种中的毒性或对任何化合物的毒性没有影响，但一个例外是OMPA对苯巴比妥处理的大鼠的毒性增加。
Summary A comparison was made of the toxicity of 15 cholinergic organic phosphates to normal rats and mice and to animals pretreated with phenobarbital for 5 days. The purpose of the study was to determine whether the hepatic microsomal enzyme induction caused by phenobarbital changed the acute toxicity of the organic phosphates. The study demonstrated that phenobarbital treatment either decreased the toxicity or had no effect on the toxicity of any of the compounds in either species with one exception being an increased toxicity of OMPA to phenobarbitaltreated rats.