Regenerative medicine and developmental biology: The role of the extracellular matrix
Regenerative medicine and developmental biology: The role of the extracellular matrix
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DOI：
10.1002/ar.b.20081
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发表时间：
2005-11-01
期刊：
影响因子：
--
通讯作者：
Badylak, Stephen F.
中科院分区：
文献类型：
--
作者：
Badylak, Stephen F.
再生医学和发育生物学的原理和最终目标涉及一系列复杂的事件，最终形成结构和功能正常的组织和器官。细胞外基质（ECM）的分子组成在细胞迁移和分化事件中起着关键作用。哺乳动物细胞外基质来源于各种组织和器官，已被用作生物支架用于治疗再生应用。成千上万的人类患者受益于使用由天然发生的ECM组成的生物支架。ECM诱导建设性重塑而不是瘢痕组织形成的机制才刚刚开始被理解。本文综述了哺乳动物ECM的组成，其在发育生物学中的作用，以及使用这种天然支架所产生的临床应用。
The principles and ultimate goals of regenerative medicine and developmental biology involve a complex sequence of events, culminating in the formation of structurally and functionally normal tissues and organs. The molecular composition of the extracellular matrix (ECM) plays a critical role in cellular migration and differentiation events. Mammalian ECM, derived from various tissues and organs, has been used as a biologic scaffold for therapeutic regenerative applications. Hundreds of thousands of human patients have benefited from the use of biologic scaffolds composed of naturally occurring ECM. The mechanisms by which ECM induces constructive remodeling instead of scar tissue formation are only beginning to be understood. This article reviews composition of mammalian ECM, its poorly understood role in developmental biology, and the clinical applications that have resulted from the use of this naturally occurring scaffold.