The action of caerulein on pancreatic and biliary secretions of the chicken.
The action of caerulein on pancreatic and biliary secretions of the chicken.
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DOI：
10.1016/0014-2999(70)90051-8
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发表时间：
1970-07
影响因子：
5
通讯作者：
L. Angelucci;M. Baldieri;G. Linari
中科院分区：
文献类型：
--
作者：
L. Angelucci;M. Baldieri;G. Linari
静脉滴注雨蛙素对鸡胰腺分泌有较强的刺激作用。阈值速率为0.1-0.25 ng/kg/min。皮下注射证明无效，高达5 μ g/kg;通过快速静脉注射，仅在50 ng/kg时表现出作用。雨蛙肽增加了液体、碳酸氢盐和酶的输出，大大提高了酶的浓度。阿托品仅抑制雨蛙肽对酶浓度的影响。猪促胰液素对鸡胰腺分泌无影响。雨蛙肽还能刺激肝胆汁的流动和胆汁固体成分的排出。阈值剂量为：快速静脉注射10 ng/kg，静脉输注0.5 ng/kg/min。这些作用不受阿托品的抑制。雨蛙肽可促进BSP的血浆清除和胆汁排泄。此外，它通过刺激胆囊运动增加胆囊胆汁的输出。雨蛙肽对胰腺或胆汁分泌物的快速耐受性未见。猪促胰液素通过静脉输注减少肝胆汁的流量。对雨蛙肽的作用机理进行了讨论。
Caerulein, by intravenous infusion, had a strong stimulating action on the chicken's pancreatic secretion. Threshold rates were 0.1–0.25 ng/kg/min. Subcutaneous injection proved ineffective up to 5 mug/kg; by rapid intravenous injection the action was manifest only with 50 ng/kg. Caerulein increased output of fluid, bicarbonate and enzymes, greatly enhancing the enzyme concentration. Atropine inhibited the effect of caerulein on enzyme concentration only. Porcine secretin had no effect on the chicken's pancreatic secretion. Flow of hepatic bile and the output of solid biliary components were also stimulated by caerulein. The threshold doses were: 10 ng/kg by rapid intravenous injection, and 0.5 ng/kg/min by intravenous infusion. These actions were not inhibited by atropine. Caerulein hastened plasma clearance and biliary excretion of BSP. Furthermore, it increased output of cystic bile by stimulating gall bladder motility. Tachyphylaxis to effects of caerulein on pancreastic or biliary secretions was not seen. Porcine secretin reduced the flow of hepatic bile by intravenous infusion. The mechanism of action of caerulein is discussed.