Modeling Infectious Diseases of the Central Nervous System with Human Brain Organoids.
Modeling Infectious Diseases of the Central Nervous System with Human Brain Organoids.
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DOI：
10.1016/j.trsl.2022.06.013
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发表时间：
2022-07
期刊：
影响因子：
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通讯作者：
Thanthrige Thiunuwan Priyathilaka;C. Laaker;Melinda Herbath;Z. Fabry;M. Sandor
中科院分区：
文献类型：
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作者：
Thanthrige Thiunuwan Priyathilaka;C. Laaker;Melinda Herbath;Z. Fabry;M. Sandor
已知细菌、真菌、病毒和原生动物感染并诱发人类中枢神经系统（CNS）中的疾病。病原体和CNS微环境之间相互作用的机制建模对于了解其病理生理学和开发新的治疗方法至关重要。干细胞技术的最新进展允许创建人脑类器官，与经典的二维（2D）培养物相比，人脑类器官更接近于人类CNS微环境。现在，研究人员可以利用这些系统来研究和重新研究与人类脑类器官系统中CNS感染相关的问题。在这篇综述中，我们重点介绍了几种在人脑类器官中进行过测试的传染病，并比较了不同研究中对这些病原体的相似性。我们还简要概述了最近的一些进展，这些进展可以进一步丰富该模型，以开发新的更好的治疗脑感染的疗法。
Bacteria, fungi, viruses, and protozoa are known to infect and induce diseases in the human central nervous system (CNS). Modeling the mechanisms of interaction between pathogens and the CNS microenvironment is essential to understand their pathophysiology and develop new treatments. Recent advancements in stem cell technologies have allowed for the creation of human brain organoids, which more closely resembles the human CNS microenvironment when compared to classical 2-dimensional (2D) cultures. Now researchers can utilize these systems to investigate and reinvestigate questions related to CNS infection in a human-derived brain organoid system. Here in this review, we highlight several infectious diseases which have been tested in human brain organoids and compare similarities in response to these pathogens across different investigations. We also provide a brief overview of some recent advancements which can further enrich this model to develop new and better therapies to treat brain infections.