Creating 3D Objects with Integrated Electronics via Multiphoton Fabrication In Vitro and In Vivo
Creating 3D Objects with Integrated Electronics via Multiphoton Fabrication In Vitro and In Vivo
复制标题
DOI：
10.1002/admt.202201274
复制
发表时间：
2023-03-12
影响因子：
6.8
通讯作者：
Hardy, John G.
中科院分区：
文献类型：
--
作者：
Baldock, Sara J.;Kevin, Punarja;Hardy, John G.
使用依赖于多光子制造（直接激光写入，（DLW））的增材制造方法来生产具有集成电子器件的3D物体。导电聚合物基结构（具有微米-毫米尺度特征）被印刷在示例性基质内，包括弹性体（聚二甲基硅氧烷，（PDMS））已经被广泛研究用于生物医学应用。在PDMS中的印刷过程的保真度进行评估，通过光学相干断层扫描，和导电聚合物结构被证明是能够刺激小鼠脑组织在体外。此外，在活体线虫（秀丽隐杆线虫）中证明了该方法在体内打印结构的适用性。这些结果突出了这种增材制造方法生产下一代先进材料技术的潜力，特别是用于技术和医疗应用的集成电子产品（例如，人机接口）。
3D objects with integrated electronics are produced using an additive manufacturing approach relying on multiphoton fabrication (direct laser writing, (DLW)). Conducting polymer-based structures (with micrometer-millimeter scale features) are printed within exemplar matrices, including an elastomer (polydimethylsiloxane, (PDMS)) have been widely investigated for biomedical applications. The fidelity of the printing process in PDMS is assessed by optical coherence tomography, and the conducting polymer structures are demonstrated to be capable of stimulating mouse brain tissue in vitro. Furthermore, the applicability of the approach to printing structures in vivo is demonstrated in live nematodes (Caenorhabditis elegans). These results highlight the potential for such additive manufacturing approaches to produce next-generation advanced material technologies, notably integrated electronics for technical and medical applications (e.g., human-computer interfaces).