Determination of gas-phase produced ethyl parathion and toluene 2,4-diisocyanate by ion mobility spectrometry, gas chromatography and liquid chromatography
Determination of gas-phase produced ethyl parathion and toluene 2,4-diisocyanate by ion mobility spectrometry, gas chromatography and liquid chromatography
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DOI：
10.1016/j.talanta.2006.12.022
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发表时间：
2007-05-15
期刊：
影响因子：
6.1
通讯作者：
Sillanpaa, Mika
中科院分区：
文献类型：
--
作者：
Nousiainen, Marjaana;Perakorpi, Kaleva;Sillanpaa, Mika
乙基对硫磷和甲苯2，4-二异氰酸酯(2，4-TDI)蒸汽是用蒸汽发生系统产生的，该系统是为以已知流速蒸发液体样品而设计的。对硫磷和2，4-TDI的蒸汽产生是一个挑战，因为它们的挥发性低，而且容易被蒸汽产生系统的表面吸收。采用气相色谱-质谱法(GC-MS)测定对硫磷的实验浓度。将2，4-TDI与1-(2-吡啶基)哌嗪进行衍生化反应，制得尿素类化合物，用高效液相色谱(HPLC)对其浓度进行分析。此外，结合蒸气发生器，吸气IMS被用于监测离子迁移率池(IMCell)和半导体池(SCCell)对对硫磷和2，4-TDI蒸气的响应。层析结果与IMCell反应数据有很好的相关性，表明IMS对对硫磷和2，4-TDI具有很高的特异性。在IMS的检测下限，对硫磷和2，4-TDI的浓度显著低于对硫磷或2，4-TDI的IDLH值，表明IMS对这两种化合物具有较高的灵敏度。分析了两种化学物质的IMS图谱以及湿度对IMcell和SCcell敏感性的影响。(C)2007 Elsevier B.V.保留所有权利。
Ethyl parathion and toluene 2,4-diisocyanate (2,4-TDI) vapors were generated using a vapor generation system that was designed for the evaporation of liquid samples at known flow rates. The vapor generation of parathion and 2,4-TDI posed a challenge because of their low volatility and tendency to absorb into surfaces of the vapor generation system. Experimental concentration of parathion was determined using gas chromatography-mass spectrometry (GC-MS). 2,4-TDI was derivatized with 1-(2-pyridyl)piperazine to urea derivative which concentration was analyzed using high performance liquid chromatography (HPLC). In addition, in combination with vapor generator, aspiration IMS was used for monitoring ion mobility cell (IMCell) and semiconductor cell (SCCell) responses to parathion and 2,4-TDI vapors. The chromatographic results correlated well with the IMCell response data, showing high specificity of IMS to parathion and 2,4-TDI. The concentrations of parathion and 2,4-TDI at the detection limit of IMS were significantly lower than IDLH threshold values of parathion or 2,4-TDI, demonstrating high sensitivity of IMS to both compounds. The IMS patterns of both chemicals and the influence of humidity on IMCell and SCCell sensitivity were analyzed. (C) 2007 Elsevier B.V. All rights reserved.