Sphingolipids and Lipoproteins in Health and Metabolic Disorders.
Sphingolipids and Lipoproteins in Health and Metabolic Disorders.
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DOI：
10.1016/j.tem.2017.03.005
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Hussain MM
中科院分区：
文献类型：
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作者：
Iqbal J;Walsh MT;Hammad SM;Hussain MM
鞘磷脂是一类结构和功能多样的分子，具有重要的生理功能，与细胞膜和血浆脂蛋白有关。在几种代谢紊乱中，神经鞘脂的细胞和血浆浓度会发生改变，并可作为预后和诊断标记物。在这里，我们讨论不同的鞘脂转运机制，并强调细胞和血浆鞘脂水平的变化如何有助于心血管疾病、肥胖、糖尿病、胰岛素抵抗和非酒精性脂肪性肝病。了解细胞内转运、分泌和胞外转运的机制可能会为各种代谢疾病的治疗靶向提供新的信息。
Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingolipids are altered in several metabolic disorders and may serve as prognostic and diagnostic markers. Here, we discuss different sphingolipid transport mechanisms and highlight how changes in cellular and plasma sphingolipids levels contribute to cardiovascular disease, obesity, diabetes, insulin resistance and nonalcoholic fatty liver disease. Understanding mechanisms involved in intracellular transport, secretion and extracellular transport may provide novel information that might be amenable to therapeutic targeting in the treatment of various metabolic disorders.