Melanoma Cell Membrane Biomimetic Versatile CuS Nanoprobes for Homologous Targeting Photoacoustic Imaging and Photothermal Chemotherapy
Melanoma Cell Membrane Biomimetic Versatile CuS Nanoprobes for Homologous Targeting Photoacoustic Imaging and Photothermal Chemotherapy
复制标题
黑色素瘤细胞膜仿生多功能 CuS 纳米探针，用于同源靶向光声成像和光热化疗。
DOI：
10.1021/acsami.9b23177
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发表时间：
2020-04-08
影响因子：
9.5
通讯作者：
Chen, Bingdi
中科院分区：
文献类型：
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作者：
Wu, Minliang;Mei, Tianxiao;Chen, Bingdi
调节纳米粒的表面性质是实现免疫逃逸、延长血液滞留时间、增强靶向给药能力的重要途径。将癌细胞膜伪装到纳米粒子上是增强纳米粒子主动靶向能力的理想途径。本文中，我们分离黑色素瘤细胞的膜以涂覆多柔比星（DOX）和吲哚菁绿色（ICG）负载的中空硫化铜纳米颗粒（ID-HCuSNP@ B16 F10）用于靶向光热治疗、光声成像和化疗。经ID-HCuSNP@ B16 F10处理后，在B16 F10细胞中可以观察到照射和同源靶向后的显著体外抗癌效果。此外，ID-HCuSNP@ B16 F10在黑色素瘤动物模型中表现出优异的光热效应，并实现了高肿瘤消融率。该仿生系统能够实现高载药效率、增强靶向能力和理想的抗肿瘤效果。
Modulating the surface properties of nanoparticles (NPs) is an important approach to accomplish immune escape, prolonged the blood retention time, and enhance the ability of targeted drug delivery. The camouflage of cancer cell membrane onto nanoparticles has been proved to be an ideal approach to enhance active targeting ability of NPs. Herein, we isolated the membrane of melanoma cells to coat doxorubicin (DOX) and indocyanine green (ICG)-loaded hollow copper sulfide NPs (ID-HCuSNP@B16F10) for targeted photothermal therapy, photoacoustic imaging, and chemotherapy. A remarkable in vitro anticancer effect after irradiation and homologous targeting can be observed in B16F10 cells after the treatment of ID-HCuSNP@ B16F10. Moreover, ID-HCuSNP@B16F10 exhibits excellent photothermal effect in melanoma animal models and achieves a high tumor ablation rate. This biomimetic system can realize high drug loading efficiency, enhanced targeting ability, and ideal antitumor efficiency.