Orexin synthesis and response in the gut
Orexin synthesis and response in the gut
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DOI：
10.1016/s0896-6273(00)81041-7
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发表时间：
1999-12-01
期刊：
影响因子：
16.2
通讯作者：
Liu, MT
中科院分区：
文献类型：
--
作者：
Kirchgessner, AL;Liu, MT
食欲素（hypocretin）似乎在能量平衡的调节中发挥作用。以往的研究表明，含食欲素的神经元只存在于下丘脑外侧区。我们发现，在肠道中的神经元，也表达瘦素受体显示食欲素样免疫反应性和表达功能性食欲素受体的一个子集。食欲素兴奋豚鼠粘膜下神经丛中的分泌运动神经元并增加运动。此外，禁食上调磷酸化形式的cAMP反应元件结合蛋白（pCREB）的食欲素免疫反应神经元，表明在这些细胞的食物状态的功能反应。总之，这些数据表明，食欲素在肠道中可能发挥更密切的作用，在调节能量稳态比它在中枢神经系统。
Orexin (hypocretin) appears to play a role in the regulation of energy balances. Previous reports have indicated that orexin-containing neurons are found only in the lateral hypothalamic (LH) area. We show that a subset of neurons in the gut which also express leptin receptors display orexin-like immunoreactivity and express functional orexin receptors. Orexin excites secretomotor neurons in the guinea pig submucosal plexus and increases motility. Moreover, fasting upregulates the phosphorylated form of cAMP response element-binding protein (pCREB) in orexin-immunoreactive neurons, indicating a functional response to food status in these cells. Together, these data suggest that orexin in the gut may play an even more intimate role in regulating energy homeostasis than it does in the CNS.