Association between Left-Handedness and Gastrointestinal Symptoms
Association between Left-Handedness and Gastrointestinal Symptoms
复制标题
左利手与胃肠道症状之间的关联
作者：
Y. Fujiwara;Makiko Kubo;Y. Kohata;H. Yamagami;T. Tanigawa;Kenji Watanabe;Toshio Watanabe;K. Tominaga;T. Arakawa
目的：多项研究表明，左撇子与几种慢性疾病如支气管哮喘和炎症性肠病有关。脑-肠轴的知觉反应在功能性胃肠道(GI)疾病的主要症状的发生发展中起着至关重要的作用，包括消化不良和肠易激综合征(IBS)。这项研究的目的是确定左撇子和胃肠道症状或疾病之间的联系。方法：2447名接受常规体检的日本人填写了一份自我报告问卷，内容包括年龄、性别、用字利手和过去3个月所经历的胃肠道症状，包括烧心、反酸、上腹痛、餐后胀满、腹痛/不适、恶心和/或胸痛。当症状出现频率为每月2~3天或以上时，症状呈阳性。消化不良和肠易激综合征的诊断按罗马III综合问卷进行。结果：177例(7.2%)为左撇子。左撇子较少观察到早期饱腹感、腹痛/饱腹感和餐后饱腹感。在调整了年龄和性别后，左撇子与早期饱足的OR显著相关(OR=0.43；95%CI：0.23-0.78)。左撇子与胃食道反流病(GERD)、消化不良或IBS之间没有显著关联。结论：这项研究表明，左撇子和早期饱足之间存在显著的负相关。研究结果表明，大脑偏侧可能影响胃肠道症状的发展。
Objective: Several studies have shown associations between left-handedness and several chronic diseases such as bronchial asthma and inflammatory bowel disease. Perceptual responses within the brain-gut axis play a crucial role in the development of the cardinal symptoms of functional gastrointestinal (GI) diseases, including dyspepsia and irritable bowel syndrome (IBS). The aim of this study was to determine the association between left-handedness and GI symptoms or diseases. Methods: 2,447 Japanese who underwent a routine health check-up were asked to complete a self-report questionnaire regarding age, gender, writing handedness and GI symptoms experienced over the past 3 months, including heartburn, acid regurgitation, epigastric pain, postprandial fullness, abdominal pain/discomfort, nausea and/or chest pain. Symptoms were positive when their frequency was 2 to 3 days per month or more. Diagnosis of dyspepsia and IBS was performed according to the Rome III Integrative Questionnaire. Results: Left-handedness was observed in 177 (7.2%) subjects. Early satiation, abdominal pain/fullness and postprandial fullness were less commonly observed in left-handed individuals. After adjustment for age and sex, left-handedness was found to be significantly associated with decreased OR for early satiation (OR = 0.43; 95% CI: 0.23–0.78). There were no significant associations between left-handedness and GERD (gastroesophageal reflux disease), dyspepsia or IBS. Conclusions: This study demonstrated a significant negative association between left-handedness and early satiation. The findings suggest that cerebral lateralization may affect the development of GI symptoms.
DOI：
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发表时间：
2006
期刊：
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影响因子：
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作者：
E. Mayer;David C. Metz;W. El-Deiry;Anil K Rustgi
通讯作者：
E. Mayer;David C. Metz;W. El-Deiry;Anil K Rustgi