Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease
Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease
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DOI：
10.1016/j.neuroimage.2008.02.019
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发表时间：
2008-06-01
期刊：
影响因子：
5.7
通讯作者：
Henkelman, R. Mark
中科院分区：
文献类型：
--
作者：
Lerch, Jason P.;Carroll, Jeffrey B.;Henkelman, R. Mark
最近的一项研究发现，患有亨廷顿病（HD）的YAC128小鼠模型和野生型小鼠在大脑皮层的局部区域存在差异。然而，很少有工具可以自动检查老鼠大脑皮层的形状差异。本文描述了一种从固定小鼠脑标本的MRI中自动测量整个皮质厚度的算法。对该方法方差的分析表明，平均而言，使用磁共振扫描可以测量50 μ m （0.05 mm）的局部皮质厚度差异。将这些方法应用于代表HD早期阶段的8个月大的YAC128小鼠模型小鼠，我们发现感觉运动皮层皮层厚度增加，并且还发现纹状体体积减少与皮层厚度增加相关的区域，表明潜在的代偿反应。(c) 2008爱思唯尔公司版权所有。
A recent study found differences in localised regions of the cortex between the YAC128 mouse model of Huntington's Disease (HD) and wild-type mice. There are, however, few tools to automatically examine shape differences in the cortices of mice. This paper describes an algorithm for automatically measuring cortical thickness across the entire cortex from MRI of fixed mouse brain specimens. An analysis of the variance of the method showed that, on average, a 50 mu m (0.05 mm) localised difference in cortical thickness can be measured using MR scans. Applying these methods to 8-month-old YAC128 mouse model mice representing an early stage of HD, we found an increase in cortical thickness in the sensorimotor cortex, and also revealed regions wherein decreasing striatal volume correlated with increasing cortical thickness, indicating a potential compensatory response. (c) 2008 Elsevier Inc. All rights reserved.