Synthesis of 2-(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamidoethyl-d(4) Dihydrogen Phosphate, Tetra-deuterated pAEA.
Synthesis of 2-(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamidoethyl-d(4) Dihydrogen Phosphate, Tetra-deuterated pAEA.
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2-(5Z,8Z,11Z,14Z)-二十-5,8,11,14-四烯酰胺乙基-d(4)磷酸二氢酯、四氘代 pAEA 的合成。
DOI:
10.1002/jlcr.1540
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发表时间:
2008
影响因子:
1.8
通讯作者:
Rice,KennerC
中科院分区:
文献类型:
--
作者:
Cheng,Kejun;Saha,Bijali;Mahadevan,A;Razdan,RajK;Kunos,George;Jacobson,ArthurE;Rice,KennerC
A labile intermediate phospho‐anandamide (2‐(5Z,8Z,11Z,14Z)‐icosa‐5,8,11,14‐tetraenamidoethyl dihydrogen phosphate, pAEA) has been identified in mouse brain and macrophages, but its precise quantitation was difficult because of its low concentration and chemical instability. We report the synthesis of tetra‐deuterated pAEA from 2‐aminoethyl dihydrogen phosphate‐1,1,2,2‐d4and (5Z,8Z,11Z,14Z)‐2,5‐dioxopyrrolidin‐1‐yl icosa‐5,8,11,14‐tetraenoate. The compound will be used to quantitate the pAEA necessary for a novel biosynthetic pathway. Published in 2008 by John Wiley & Sons, Ltd.
影响因子:
56.9
作者:
DEVANE, WA;HANUS, L;MECHOULAM, R
通讯作者:
MECHOULAM, R
DOI:
--
发表时间:
1961
期刊:
影响因子:
--
作者:
J. Weisburger;W. Schneider
通讯作者:
W. Schneider