Assessment of the age-specific disability weight of chronic schistosomiasis japonica
Assessment of the age-specific disability weight of chronic schistosomiasis japonica
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DOI：
10.2471/blt.06.033035
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发表时间：
2007-06-01
期刊：
影响因子：
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通讯作者：
Wu, Xiao-Hua
中科院分区：
文献类型：
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作者：
Jia, Tie-Wu;Zhou, Xiao-Nong;Wu, Xiao-Hua
目的估算中国慢性血吸虫病患者的年龄别失能权重。方法2004年10月至2005年1月，采用酶联免疫吸附试验（ELISA）对中国两个慢性血吸虫病流行县的居民进行血吸虫病筛查。使用欧洲生活质量问卷（包括额外的认知维度（称为“EQ-51 D plus”））和超声检查评估血清阳性个体的残疾和发病率。根据调查问卷中的视觉模拟量表的自评健康评分，估计慢性血吸虫病的年龄别残疾权重;采用多水平回归模型研究了健康状况、发病率和残疾体重之间的关系。慢性血吸虫病占49.9%，肝肿大占76.3%肝纤维化发生率为73.3%（1040/1419），脾肿大发生率为18.6%（264/1419）。腹泻是最常见的自我报告症状（46.0%; 653/1419），其次是腹痛（32.6%; 463/1419），工作或学习能力受损（30.7%; 436/1419）和便血（11. 1%; 157/1419）。超过一半的受访者报告了EQ-51 D plus问卷中至少一个维度的损伤，特别是疼痛或不适（47.9%; 675/1410）和焦虑或抑郁（39.4%; 555/1410）。整体残疾权重为0。19 1，年龄别加权数从5-14岁的0.095到≥ 60岁的0.246不等。多因素回归分析表明，残疾重与性别、肝纤维化程度、肝肿大、腹痛、便血、劳动或学习能力受损、认知功能障碍显著相关。结论慢性血吸虫病患者的残疾重较高，且随年龄增长而增加。我们的研究结果要求重新评估慢性曼氏血吸虫病和血友病的残疾权重，以及重新估计血吸虫病的全球负担。
Objective To estimate the age-specific disability weight of chronic schistosomiasis japonica in China.Methods Between October 2004 and January 2005, residents from two schistosome-endemic counties were screened for Schistosomajaponicum infection using an enzyme-linked immunosorbent assay. Disability and morbidity were assessed in seropositive individuals using the European quality of life questionnaire with an additional cognitive dimension (known as the "EQ-51D plus") and ultrasonography. The age-specific disability weight of chronic schistosomiasis was estimated based on participants' self-rated health scores on the visual analogue scale of the questionnaire; the relationships between health status, morbidity and disability weight were explored using multilevel regression models.Findings Of 2843 seropositive individuals, 1419 (49.9%) were classified as having chronic schistosomiasis, Hepatomegaly was found in 76.3% (1082/1419); hepatic fibrosis was found in 73.3% (1040/1419); and splenomegaly was found in 18.6% (264/1419). Diarrhoea was the most common self-reported symptom (46.0%; 653/1419), followed by abdominal pain (32.6%; 463/1419), impaired capacity to work or study (30.7%; 436/1419), and blood in the stool (11. 1 %; 157/1419). More than half of the respondents reported impairments in at least one dimension of the EQ-51D plus questionnaire, particularly pain or discomfort (47.9%; 675/1410) and anxiety or depression (39.4%; 555/1410). The overall disability weight was 0. 19 1, and age-specific weights ranged from 0.095 among those aged 5-14 years to 0.246 among those aged >= 60 years. Multilevel regression models indicated that the disability weight was significantly associated with the participant's sex, grade of hepatic fibrosis, the presence of hepatomegaly, abdominal pain, blood in the stool, impaired capacity to work or study, and cognition.Conclusion The disability weight attributable to chronic schistosomiasis japonica is high and increases with age. Our findings call for a reappraisal of the disability weights due to chronic schistosomiasis mansoni and schistosorniasis haematobia as well as a reestimation of the global burden of schistosomiasis.