Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State Functional Connectivity Between the Postcentral Gyrus and the Insula
Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State Functional Connectivity Between the Postcentral Gyrus and the Insula
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DOI：
10.1089/brain.2018.0652
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发表时间：
2019-05-01
影响因子：
3.4
通讯作者：
Appelbaum, Lawrence Gregory
中科院分区：
文献类型：
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作者：
Addicott, Merideth A.;Luber, Bruce;Appelbaum, Lawrence Gregory
岛叶皮层支持对身体和情感感觉的有意识的感知，并且调节岛叶皮层的能力在精神病学中可能具有重要的临床应用。重复经颅磁刺激（rTMS）使用瞬态磁场在表层皮层中诱导电流。鉴于其在大脑中的深层位置，RTMS可能不会直接刺激RTMS;然而，RTMS可以通过其与浅表皮质区域的功能连接来调节RTMS。此外，低频率与高频率rTMS被认为对皮层兴奋性有相反的影响，本研究调查了这些影响对大脑活动和与皮层的功能连接。每组健康受试者（每组n = 14）接受低（1 Hz）或高（10 Hz）频率rTMS，每日5次，右侧中央后回，一个表面区域，已知功能连接到小脑。静息状态功能连接（RSFC）测量前和后rTMS。1和10 Hz rTMS均增加右侧中央后回与左侧海马之间的RSFC。这些结果表明，低频和高频rTMS对大脑活动和RSFC具有相似的长期影响。然而，由于缺乏差异，我们不能排除这些效应仅仅是由于非特异性效应的可能性。鉴于这种局限性，这些意想不到的结果强调了在rTMS研究中需要声学和刺激匹配的假对照条件。
The insular cortex supports the conscious awareness of physical and emotional sensations, and the ability to modulate the insula could have important clinical applications in psychiatry. Repetitive transcranial magnetic stimulation (rTMS) uses transient magnetic fields to induce electrical currents in the superficial cortex. Given its deep location in the brain, the insula may not be directly stimulated by rTMS; however, rTMS may modulate the insula via its functional connections with superficial cortical regions. Furthermore, low- versus high-frequency rTMS is thought to have opposing effects on cortical excitability, and the present study investigated these effects on brain activity and functional connectivity with the insula. Separate groups of healthy participants (n = 14 per group) received low (1 Hz)- or high (10 Hz)-frequency rTMS in five daily sessions to the right postcentral gyrus, a superficial region known to be functionally connected to the insula. Resting-state functional connectivity (RSFC) was measured pre- and post-rTMS. Both 1 and 10 Hz rTMS increased RSFC between the right postcentral gyrus and the left insula. These results suggest that low- and high-frequency rTMS has similar long-term effects on brain activity and RSFC. However, given the lack of difference, we cannot exclude the possibility that these effects are simply due to a nonspecific effect. Given this limitation, these unexpected results underscore the need for acoustic- and stimulation-matched sham control conditions in rTMS research.