Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size in Y-consomic strains.
Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size in Y-consomic strains.
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DOI：
10.1186/1756-0500-6-64
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发表时间：
2013-02-18
影响因子：
1.8
通讯作者：
Suto J
中科院分区：
文献类型：
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作者：
Suto J
我们在近交DH/Sgn系中建立了17个Y染色体同源（Y-consomic）小鼠品系。本研究通过对四种不同遗传背景的小鼠的研究，证实了KK/Ta系小鼠的Y染色体与体型缩小有关。在DH-Chr Y-+/+背景下，Y染色体置换显著降低了DH-Chr YKK-+/+和DH-Chr YSJL-+/+品系的体重，其中DH-Chr YKK-+/+品系的体重最轻。在DH-Chr Y-Dh/+背景下（Dh/+小鼠有骨骼畸形，通常比+/+小鼠轻），尽管Y染色体取代没有显著改变体重，但DH-Chr YKK-Dh/+品系是17个Y染色体-Dh/+品系中最轻的。在（B6.Cg-Ay × DH-Chr Y）F1-+/+背景下，Y染色体置换使（B6.Cg-Ay × DH-Chr YKK）F1代体重和体长显著降低。在（B6.Cg-Ay × DH-Chr Y）F1-Ay/+背景下（Ay引起肥胖并促进线性生长），Y染色体替换显著降低了（B6.Cg-Ay × DH-Chr YKK）F1-Ay/+杂种的体重和身长。观察到KK/Ta小鼠品系的Y染色体的体型减小效应，而与遗传背景无关。在Dh和Ay（常染色体显性突变）存在的情况下观察到这种效应，已知这两种突变对体型有实质性影响。这些结果表明，在小鼠中存在控制体型的Y连锁基因。
We have established 17 Y chromosome consomic (Y-consomic) mouse strains in an inbred DH/Sgn strain. In this study, based on investigations in four different genetic backgrounds, we proved that the Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size. In the DH-Chr Y-+/+ background, Y chromosome substitution significantly decreased the body weight in DH-Chr YKK-+/+ and DH-Chr YSJL-+/+ strains, and the DH-Chr YKK-+/+ strain was the lightest among the 17 Y-consomic strains. In the DH-Chr Y-Dh/+ background (Dh/+ mice have skeletal malformations and are usually lighter than +/+ mice), although Y chromosome substitution did not significantly alter the body weight, the DH-Chr YKK-Dh/+ strain was the lightest among the 17 Y-consomic-Dh/+ strains. In the (B6.Cg-Ay × DH-Chr Y) F1-+/+ background, Y chromosome substitution significantly decreased the body weight and length in the (B6.Cg-Ay × DH-Chr YKK) F1 hybrids. In the (B6.Cg-Ay × DH-Chr Y) F1-Ay/+ background (Ay causes obesity and promotes linear growth), Y chromosome substitution significantly decreased body weight and length in the (B6.Cg-Ay × DH-Chr YKK) F1-Ay/+ hybrids. A body-size-reducing effect of the Y chromosome of the KK/Ta mouse strain was observed irrespective of genetic background. The effect was observed in the presence of Dh and Ay, the autosomal dominant mutations, both of which are known to have substantial effects on body size. These results suggest that there are Y-linked genes that control the body size in mice.