A porphyrin photosensitized metal-organic framework for cancer cell apoptosis and caspase responsive theranostics
A porphyrin photosensitized metal-organic framework for cancer cell apoptosis and caspase responsive theranostics
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用于癌细胞凋亡和半胱天冬酶响应治疗诊断的卟啉光敏金属有机框架
DOI：
10.1039/c5cc03028e
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Ju, Huangxian
中科院分区：
文献类型：
--
作者：
Zhang, Lei;Lei, Jianping;Ju, Huangxian
通过将卟啉、叶酸靶向基序和染料标记肽组装在金属有机骨架（MOF）笼中，设计了一种光敏化和半胱天冬酶响应的多功能纳米探针，使卟啉的单线态氧量子产率显著提高6.2倍，实现了高效的肿瘤治疗和半胱天冬酶-3激活的原位治疗监测。在单个纳米载体中整合治疗诊断功能在精确的癌症诊断和治疗中具有很大的前景。
A photosensitized and caspase-responsive multifunctional nanoprobe was designed by assembling a porphyrin, a folate targeting-motif and a dye-labelled peptide in a metal-organic framework (MOF) cage, which significantly increases the singlet oxygen quantum yield of porphyrin by 6.2 times, and achieves high efficient cancer therapy and in situ therapeutic monitoring with caspase-3 activation. The integration of theranostic functions in a single nanocarrier holds great promise in precision cancer diagnosis and treatment.