Stress and high sodium effects on blood pressure and brain catecholamines in spontaneously hypertensive rats.
Stress and high sodium effects on blood pressure and brain catecholamines in spontaneously hypertensive rats.
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压力和高钠对自发性高血压大鼠的血压和脑儿茶酚胺的影响。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
J. Weigand
中科院分区：
文献类型：
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作者：
D. Ely;J. Weigand
本实验旨在确定区域应激、膳食钠(Na)或应激与钠的结合是否影响自发性高血压大鼠(SHR 4-18周)的高血压发展速度，以及这些处理是否改变中枢儿茶酚胺(C)。与SHR对照组相比，应激治疗2-8周后血压显著升高。应激组孤束核和杏仁核的去甲肾上腺素(NE)水平以及海马和A区的多巴胺(D)水平显著升高。与对照SHR相比，高钠(3%)联合应激处理使杏仁核的血压进一步升高，D水平升高，最后区域的NE水平升高。选定的脑C变量能够正确地将动物分为高血压组和低血压组，准确率为90-100%。我们的数据支持这一观点，即在SHR中存在重要的应激和钠效应对脑神经化学影响高血压的发展。
The following experiments were designed to determine if territorial stress, dietary sodium (Na), or the combination of stress and Na effect the rate of development of hypertension in the spontaneously hypertensive rat (SHR 4-18 wks) and if central catecholamines (C) were altered by these treatments. BP was significantly elevated from 2-8 weeks of stress treatment as compared to SHR controls. Norepinephrine (NE) levels in the nucleus tractus solitarius and amygdala (A), and dopamine (D) levels in the hippocampus and A showed significant elevations in the stressed group. High Na (3%) treatment combined with stress treatment produced an even further BP increase and elevated D levels in the amygdala, and elevated NE levels in the area postrema as compared to control SHR's. Selected brain C variables were able to correctly classify animals into high and low BP groups with 90-100% accuracy. Our data support the concept that there are important stress and Na effects upon brain neurochemistry which influence the development of hypertension in the SHR.