The relationship of hepatitis B surface antigen and antibody to atomic bomb radiation in the Adult Health Study sample, 1975-1977.
The relationship of hepatitis B surface antigen and antibody to atomic bomb radiation in the Adult Health Study sample, 1975-1977.
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1975-1977 年成人健康研究样本中乙型肝炎表面抗原和抗体与原子弹辐射的关系。
DOI：
10.1093/oxfordjournals.aje.a113584
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发表时间：
1983
影响因子：
5
通讯作者：
H. Hamilton
中科院分区：
文献类型：
--
作者：
H. Kato;M. Mayumi;K. Nishioka;H. Hamilton
在1975 ~ 1977年两年期间，对日本广岛和长崎的2566名原子弹爆炸幸存者进行了B表面抗原（HBsAg）和抗体（抗-HBs）阳性率的测定。暴露于100拉德或更高剂量的受试者HBsAg阳性频率（79%的受试者保持持续抗原阳性）显著高于对照组。接触组之间的这种差异在较年轻的年龄组中更为明显。然而，与预期相反，在抗原阳性个体中，高滴度与低滴度的分布在剂量组之间没有差异。两个对照组之间在阳性抗-HBs反应（B型肝炎病毒的流行率）的发生率方面没有差异。上述结果表明，使用HBsAg阳性率作为指标，免疫能力在高剂量组中受到抑制，但需要进一步研究，包括对持续HBsAg阳性反应的患者进行随访。就HBsAg亚型而言，与广岛相比，长崎的adr发生频率较高，adw发生频率较低，这与日本群岛这两种亚型的反向和互补分布的早期报告相对应。
A frequency of positive hepatitis B surface antigen (HBsAg) and antibody (anti-HBs) was determined among 2566 atomic bomb survivors in Hiroshima and Nagasaki, Japan during the two-year period 1975 to 1977. The frequency of positive HBsAg (79% of subjects remained persistently antigen positive) was significantly higher in those exposed to 100 rad or more than in the controls. This difference between exposure groups was more marked among the younger age groups. However, contrary to expectation, there was no difference between the dose groups in the distribution by high vs. low titers among the antigen-positive individuals. There was no difference between the two comparison groups in the occurrence of positive anti-HBs reactions (prevalence of hepatitis B virus). The above findings suggest that immune competence, using the prevalence of positive HBsAg as an index, is depressed in the high dose group, but further study, including follow-up of those with persistent positive HBsAg reactions, is called for. With respect to HBsAg subtypes, adr occurs with higher and adw with lower frequency in Nagasaki than in Hiroshima, corresponding to earlier reports for the Japan archipelago of reverse and complementary distributions of these two subtypes.