Stiffening transition in asymmetric lipid bilayers: The role of highly ordered domains and the effect of temperature and size
Stiffening transition in asymmetric lipid bilayers: The role of highly ordered domains and the effect of temperature and size
复制标题
不对称脂质双层的硬化转变：高度有序结构域的作用以及温度和尺寸的影响
DOI：
10.1063/5.0028255
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Deserno, Markus
中科院分区：
文献类型：
--
作者：
Hossein, Amirali;Deserno, Markus
146a 2021年2月24日星期三，屈曲的拐点是形成此类结构域的首选。阈值不对称性随温度增加，表明向硬化制度的过渡可能被限制在高于对称膜的凝胶转变温度的有限温度范围内。我们还看到，如果在相同的温度下比较，具有更多有序尾部的脂质类型在较小的不对称性下发生硬化。此外，我们表明，硬化更容易发生较大的膜具有较小的典型曲率，这表明硬化过渡是更容易观察到的实验比在小规模的系统模拟。
146a Wednesday, February 24, 2021 the inflection points of buckles, are preferred for formation of such domains. The threshold asymmetry increases with temperature, indicating that the transition to a stiffened regime might be restricted to a limited temperature range above the gel transition temperature of the symmetric membrane. We also see that stiffening happens at smaller asymmetries for lipid types that have more ordered tails if compared at the same temperature. Furthermore, we show that stiffening occurs more readily for larger membranes with smaller typical curvatures, suggesting that the stiffening transition is easier to observe experimentally than in the small-scale systems accessible to simulation.