Unifying Long-Term Plasticity Rules for Excitatory Synapses by Modeling Dendrites of Cortical Pyramidal Neurons
Unifying Long-Term Plasticity Rules for Excitatory Synapses by Modeling Dendrites of Cortical Pyramidal Neurons
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DOI：
10.1016/j.celrep.2019.11.068
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发表时间：
2019-12-24
期刊：
影响因子：
8.8
通讯作者：
Cuntz, Hermann
中科院分区：
文献类型：
--
作者：
Ebner, Christian;Clopath, Claudia;Cuntz, Hermann
大量的实验已经表明，精确的尖峰时间，放电率，和突触的位置至关重要地决定了兴奋性突触的长期可塑性诱导的动力学。然而，它仍然是未知的可塑性机制分布在沿着树突树突触合作，以产生各种可塑性协议的广泛的结果。在这里，我们提出了一个四通道可塑性的框架，是很好地扎根于实验证据，并将其应用到一个生物病理学现实的皮质锥体神经元模型。我们表明，在计算机模拟中，几个看似矛盾的实验里程碑式的研究是一致的一个统一的机制时，考虑信号传播的影响，在树突状树突触位置。我们的模型确定了特定的时空贡献的树突和轴体尖峰以及阈下激活的突触簇，提供了一个统一的简约的解释，不仅为率和时间依赖性，而且为位置依赖性的突触变化。
A large number of experiments have indicated that precise spike times, firing rates, and synapse locations crucially determine the dynamics of long-term plasticity induction in excitatory synapses. However, it remains unknown how plasticity mechanisms of synapses distributed along dendritic trees cooperate to produce the wide spectrum of outcomes for various plasticity protocols. Here, we propose a four-pathway plasticity framework that is well grounded in experimental evidence and apply it to a biophysically realistic cortical pyramidal neuron model. We show in computer simulations that several seemingly contradictory experimental landmark studies are consistent with one unifying set of mechanisms when considering the effects of signal propagation in dendritic trees with respect to synapse location. Our model identifies specific spatiotemporal contributions of dendritic and axo-somatic spikes as well as of subthreshold activation of synaptic clusters, providing a unified parsimonious explanation not only for rate and timing dependence but also for location dependence of synaptic changes.