Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up.
Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up.
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DOI：
10.1007/s00246-023-03216-8
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发表时间：
2023-10
影响因子：
1.6
通讯作者：
Dorfman, Adam
中科院分区：
文献类型：
--
作者：
Detterich, Jon D.;Taylor, Michael C.;Slesnick, Timothy;DiLorenzo, Michael;Hlavacek, Anthony;Lam, Christopher Z.;Sachdeva, Shagun;Lang, Sean M.;Campbell, M. Jay;Gerardin, Jennifer;Whitehead, Kevin K.;Rathod, Rahul H.;Cartoski, Mark;Menon, Shaji;Trachtenberg, Felicia;Gongwer, Russell;Newburger, Jane;Goldberg, Caren L.;Dorfman, Adam
单心室重建(SVR)试验是一项随机前瞻性试验，旨在确定改良Blalock-Taussig-Thomas分流术(BTTS)与右室-肺动脉导管(RVPAS)治疗左心发育不良综合征患者的生存优势。长期随访(SVRIII)的主要目的是确定分流类型对RV功能的影响。在这项工作中，我们描述了CMR在SVR试验的大型队列随访中的应用，作为单心室功能的重点研究。SVRIII方案包括短轴稳态自由进动成像，以评估单心室收缩功能和血流定量。共有313名符合条件的SVRIII参与者，237人登记，年龄从10岁到12.5岁不等。177/237(75%)的参与者接受了CMR。最常见的原因是麻醉(n = 14例)或ICD/起搏器(n = 11例)。共有168/177(94%)的CMR研究被诊断为RVEF。检查时间中位数为54分钟，电影功能检查时间为20分钟，血流量化时间为18分钟。有69/177(39%)的研究指出胸腔内有伪影，最常见的是胸腔内金属产生的易感性伪影。并不是所有的人工制品都会导致非诊断性检查。这些数据描述了在一项前瞻性试验中，CMR在评估患有先天性心脏病的学龄儿童人群中的心脏功能的使用和局限性。随着CMR技术的不断进步，预计许多限制将会减少。
The Single Ventricle Reconstruction (SVR) Trial was a randomized prospective trial designed to determine survival advantage of the modified Blalock-Taussig-Thomas shunt (BTTS) vs the right ventricle to pulmonary artery conduit (RVPAS) for patients with hypoplastic left heart syndrome. The primary aim of the long-term follow-up (SVRIII) was to determine the impact of shunt type on RV function. In this work, we describe the use of CMR in a large cohort follow up from the SVR Trial as a focused study of single ventricle function. The SVRIII protocol included short axis steady-state free precession imaging to assess single ventricle systolic function and flow quantification. There were 313 eligible SVRIII participants and 237 enrolled, ages ranging from 10 to 12.5 years. 177/237 (75%) participants underwent CMR. The most common reasons for not undergoing CMR exam were requirement for anesthesia (n = 14) or ICD/pacemaker (n = 11). A total of 168/177 (94%) CMR studies were diagnostic for RVEF. Median exam time was 54 [IQR 40–74] minutes, cine function exam time 20 [IQR 14–27] minutes, and flow quantification time 18 [IQR 12–25] minutes. There were 69/177 (39%) studies noted to have intra-thoracic artifacts, most common being susceptibility artifact from intra-thoracic metal. Not all artifacts resulted in non-diagnostic exams. These data describe the use and limitations of CMR for the assessment of cardiac function in a prospective trial setting in a grade-school-aged pediatric population with congenital heart disease. Many of the limitations are expected to decrease with the continued advancement of CMR technology.
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DOI：
10.1148/ryct.2020200086
发表时间：
2020-10-01
期刊：
RADIOLOGY-CARDIOTHORACIC IMAGING
影响因子：
--
作者：
Gupta, Sanjaya K.;Ya'qoub, Lina;Saeed, Ibrahim M.
通讯作者：
Saeed, Ibrahim M.
影响因子：
2.1
作者：
Breuckmann, F;Nassenstein, K;Erbel, R
通讯作者：
Erbel, R
DOI：
10.1186/1532-429x-15-51
发表时间：
2013-06-13
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Fratz S;Chung T;Greil GF;Samyn MM;Taylor AM;Valsangiacomo Buechel ER;Yoo SJ;Powell AJ
通讯作者：
Powell AJ
影响因子：
5.1
作者：
Fogel, Mark A.;Weinberg, Paul M.;Concepcion, Mikael
通讯作者：
Concepcion, Mikael
影响因子：
19.7
作者：
Nguyen, Kim-Lien;Ghosh, Reena M.;Finn, J. Paul
通讯作者：
Finn, J. Paul