Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study
Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study
复制标题
DOI：
10.1016/j.jhep.2008.11.021
复制
发表时间：
2009-05-01
影响因子：
25.7
通讯作者：
Miao, Min
中科院分区：
文献类型：
--
作者：
Li, Youming;Xu, Chengfu;Miao, Min
背景/目的血清尿酸水平与代谢综合征的相关因素有关。为探讨血尿酸水平与非酒精性脂肪性肝病（NAFLD）的关系，采用横断面调查方法，对镇海炼化公司职工进行调查，结果：该研究包括8925名受试者（6008名男性），平均年龄为43岁。NAFLD和高尿酸血症的患病率为11.78%。和14.7%。NAFLD患者血清尿酸水平显著高于对照组（370.3 +/-86.6 vs. 321.1 +/-82.6 pmol/L; P <0.001）。高尿酸血症组NAFLD患病率显著高于非高尿酸血症组（24.75%vs.9.54%，P <0.001），且随着血尿酸水平的升高，NAFLD患病率逐渐升高（趋势P值<0.001）。多元回归分析显示，高尿酸血症与NAFLD的发病风险相关（OR：1.291，95%可信区间：1.067-1.564; P <0.001）。结论：血尿酸水平与NAFLD密切相关，血尿酸水平升高是NAFLD的独立危险因素。(c)2008年欧洲肝脏研究协会。Elsevier B.V.出版，保留所有权利。
Background/Aims Serum uric acid level has been suggested to be associated with factors that contribute to the metabolic syndrome. The aim of this study was to investigate the association of serum uric acid level with non-alcoholic fatty liver disease (NAFLD).Methods: A cross-sectional study was performed among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China.Results: The study included 8925 subjects (6008 men) with a mean age of 43 years. The prevalence rates of NAFLD and hyperuricemia were 11.78%. and 14.7%, respectively. NAFLD patients had significantly higher serum uric acid levels than controls (370.3 +/- 86.6 vs. 321.1 +/- 82.6 pmol/L; P < 0.001). The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than in those without hyperuricemia (24.75% vs. 9.54%; P < 0.001), and the prevalence rate increased with progressively higher serum uric acid levels (P value for trend < 0.001). Multiple regression analysis showed that hyperuricemia was associated with an increased risk of NAFLD (odds ratio [OR]: 1.291, 95% confidence interval [CI]: 1.067-1.564; P < 0.001).Conclusion: Serum uric acid level is significantly associated with NAFLD, and elevated serum uric acid level is an independent risk factor for NAFLD. (c) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.