Breastfeeding and risk of ovarian cancer in two prospective cohorts
Breastfeeding and risk of ovarian cancer in two prospective cohorts
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DOI：
10.1007/s10552-007-0130-2
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发表时间：
2007-06-01
影响因子：
2.3
通讯作者：
Hankinson, Susan E.
中科院分区：
文献类型：
--
作者：
Danforth, Kim N.;Tworoger, Shelley S.;Hankinson, Susan E.
目的描述母乳喂养和卵巢癌风险之间的关联在两个前瞻性cohols.Materials & Methods我们汇集了护士健康研究和护士健康研究II的数据。在149，693名经产妇女中，有391例上皮性卵巢癌被诊断，随访时间长达16年。采用多变量考克斯比例风险模型对数据进行分析，控制年龄、产次、口服避孕药使用时间、输卵管结扎和初潮年龄。（RR = 0.86，95%CI 0.70 - 1.06）;母乳喂养的妇女中位母乳喂养持续时间为9个月。与从未母乳喂养相比，母乳喂养18个月或更长时间与卵巢癌风险显著降低相关（RR = 0.66，95%CI 0.46 - 0.96）。母乳喂养每增加1个月，卵巢上皮性癌的相对危险度下降2%（RR = 0.98，95%CI 0.97-1.00）。结论母乳喂养与卵巢上皮性癌的发病呈线性负相关。
Objective To describe the association between breastfeeding and ovarian cancer risk in two prospective cohorts.Materials & methods We pooled data from the Nurses' Health Study and Nurses' Health Study II. There were 391 cases of epithelial ovarian cancer diagnosed among 149,693 parous women with up to 16 years of follow-up. Data were analyzed using multivariate Cox proportional hazards models, controlling for age, parity, duration of oral contraceptive use, tubal ligation, and age at menarche.Results Ever breastfeeding was associated with a non-significant reduction in ovarian cancer risk compared with never breastfeeding (RR = 0.86, 95% CI 0.70-1.06); the median duration of breastfeeding among women who breastfed was nine months. Breastfeeding of 18 or more months was associated with a significant decrease in ovarian cancer risk compared to never breastfeeding (RR = 0.66, 95% CI 0.46-0.96). For each month of breastfeeding the relative risk decreased by 2% (RR = 0.98 per month, 95% CI 0.97-1.00).Conclusions These data support a linear inverse association between breastfeeding and risk of epithelial ovarian cancer.