Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells
Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells
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DOI：
10.1248/jhs.55.845
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发表时间：
2009-10-01
影响因子：
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通讯作者：
Hayakawa, Kazuichi
中科院分区：
文献类型：
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作者：
Motoyama, Yumi;Bekki, Kanae;Hayakawa, Kazuichi
研究了4种邻醌型多环芳烃和7种对位醌型多环芳烃对A549细胞活力的影响。邻醌型多环芳烃[1，2-萘醌（1，2-NQ）、9，10-菲醌（9，10-PQ）、5，6-苯醌（5，6-CQ）和苯并[c]菲-5，6-醌（B[c]P-5，6-Q）]过量产生过氧化氢（H2 O2）而自身不被消耗。这些ortizo-quinoid有很强的细胞毒性作用，除了1，2-NQ，因为它的倾向，共-双结合的巯基。细胞毒性似乎是由于过量生产的过氧化氢的邻醌多环芳烃在氧化还原循环加上巯基的消耗。相比之下，对醌类多环芳烃没有那么强的细胞毒性，不产生过氧化氢。
The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,.10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortizo-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to co-valently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the paraquinoid PAHs were not as strong cytotoxic and did not produce H2O2.